杨梅素与乙醇合用对小鼠的镇痛作用

A study on the analgesic effects of myricetin and ethanol combination in mice

目的：观察杨梅素与乙醇合用对小鼠的镇痛作用。方法将小鼠随机分成4组（ n＝8）：杨梅素（ Myri）组、乙醇（ Etha）组、杨梅素＋乙醇（ Myri ＋Etha）组和生理盐水（ NS）组。用醋酸扭体试验和热板试验观察杨梅素、乙醇有无镇痛作用及二药合用有无协同。结果在醋酸扭体试验中，Myri组、Etha组、Myri＋Etha组扭体次数均减少，与Myri组、Etha组相比，Myri＋Etha组扭体次数亦减少（P＜0．05）。在热板试验中，与基础痛阈相比，Myri组、Etha组、Myri＋Etha组痛阈均提高（P＜0．05）。与Myri组、Etha组比较，Myri＋Etha组痛阈提高（P＜0．05）。结论杨梅素和乙醇有一定的镇痛作用，且杨梅素与乙醇合用能增强对小鼠的镇痛作用。

Objective To observe the analgesic effects of the combination of myricetin and ethanol on mice .Meth-ods The mice were randomly divided into 4 groups （n=8）： a myricetin （Myri） group, an ethanol （Etha） group, a myricetin ＋ethanol （Myri ＋Etha） group and a normal saline （NS） group.Then, the analgesic effects of myricetin, ethanol or both on mice were observed by the acetic acid -induced writhing test and hot plate test .Results During the acetic acid-induced writhing test , all groups presented a decreased number of writhing , where the number of writhing was remarkably lower in Group Myri ＋Etha than those in other groups （P〈0.05）.During the hot plate test, the threshold of pain were increased in all group , where markedly increases were observed in Group Myri ＋Etha than those in other groups （P〈0.05）.Conclusion Both myricetin and ethanol shows analgesic effects , while the combination of myricetin and ethanol can result in enhanced analgesic effects on mice .