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白藜芦醇在肾缺血再灌注损伤中的研究进展 被引量：1

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摘要 白藜芦醇（ resveratrol ）是一种广泛存在于葡萄皮、蓝莓、虎仗等植物中的一种脂溶性植物抗毒素，具有抗炎、抗肿瘤及抗氧化能力，已经被广泛应用到各种人类疾病模型的研究中。因其肾脏毒性低，已经在许多肾脏疾病中广泛应用。白藜芦醇具有的直接抗氧化活性，能够有效保护培养的肾小管上皮细胞抵抗脂质过氧化物（ LOOH）、H2O2等诱导的氧化应激。
作者 周磊 李海伦 郑东辉
机构地区 徐州医学院附属淮安市第二人民医院检验科 徐州医学院附属淮安市第二人民医院肾脏科
出处 《徐州医学院学报》 CAS 2016年第1期64-67,共4页 Acta Academiae Medicinae Xuzhou
基金 国家自然科学基金面上项目（81270817）
关键词 白藜芦醇 肾 缺血再灌注损伤
分类号 R96 [医药卫生—药理学]
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参考文献44

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二级参考文献17

  • 1Bottinger EP,Bitzer M. TGF-beta signaling in renal disease[J].Journal of the American Society of Nephrology,2002,(10):2600-2610.doi:10.1097/01.ASN.0000033611.79556.AE.
  • 2Li J,Qu X,Ricardo SD. Resveratrol inhibits renal fibrosis in the obstructed kidney:potential role in deacetylation of Smad3[J].American Journal of Pathology,2010.1065-1071.
  • 3Hao CM,Haase VH. Sirtuins and their relevance to the kidney[J].Journal of the American Society of Nephrology,2010.1620-1627.
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  • 8Zhang L,Pang S,Deng B. High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-kappaB/NADPH oxidase/ROS pathway,which is inhibited by resveratrol[J].International Journal of Biochemistry & Cell Biology,2012.629-638.
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  • 10Chander V,Chopra K. Protective effect of nitric oxide pathway in resveratrol renal ischemia-reperfusion injury in rats[J].Archives of Medical Research,2006.19-26.

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徐州医学院学报
2016年 第1期

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