摘要
采用微核(MN)试验和姊妹染色单体交换(SCE)试验评价了百草枯(Paraquat,PQ)对人肝Hep G2细胞的致突变性。结果显示,7.21 mg/L的PQ处理即可导致Hep G2细胞的MN率和SCE频率均明显升高,且MN率和SCE频率升高趋势均与PQ处理浓度呈正相关,至34.57 mg/L的PQ处理组,Hep G2细胞的MN率和SCE频率分别升高为正常组的5.29和6.07倍,表明PQ对人肝Hep G2细胞具有明显的致突变性。
The mutagenecity of paraquat（PQ） on human liver Hep G2 cells by micronucleus（MN） and sister chromatid exchange（SCE） assay were evaluated. The experimental results showed that MN ratio and SCE frequency of Hep G2 cells increased after the treatment of 7.21 mg / L PQ. And there was a positive correlation between the dose of PQ and the change of MN ratio and SCE frequency. When it came to the treatment group of 34.57 mg / L PQ, MN ratio and SCE frequency of Hep G2 cells rised respectively up to 5.29 and 6.07 times of the normal group. The results indicated that PQ had evident mutagenicity on human liver Hep G2 cells.
出处
《湖北农业科学》
2016年第4期896-900,共5页
Hubei Agricultural Sciences
基金
国家自然科学基金项目(31170733)
河南师范大学博士科研启动基金项目
