米枯力兹病51例临床病理分析

Mikulicz's disease:a clinicopathological analysis of 51 cases

目的:探讨米枯力兹病的病理诊断、鉴别诊断及预后等问题,为临床防治提供依据。方法:对51例米枯力兹病的临床和病理资料进行分析,并进行LCA、CD20、CD3、CD4、CD45RA、CD45RO、EMA、CEA、S-100、CK、lysozyme、EBV、IgG4、HBsAg、HBcAg免疫组织化学标记。结果:米枯力兹病的病变特征为腺实质萎缩和淋巴样组织增生。免疫组织化学标记示T和B淋巴细胞混合性增生,IgG4 80%阳性。结论:米枯力兹病为一种自身免疫性疾病,多见于绝经后女性,手术后可以复发,治疗上应辅以免疫调节剂等治疗。

Objective： To explore the pathological features, differential diagnosis and prognosis of Mikulicz＇s disease, and provide methods of treatment and prevention for clinicians. Methods： The clinical and pathological features of Mikulicz disease were analyzed in 51 patients and the expression of LCA, CD 20, CD 3, CD 4, CD 45 RA, CD 45 RO, EMA, CEA, S-100, CK, lysozyme, EBV, IgG4, HBsAg and HBcAg in Mikulicz disease were detected immunohistochemically. Results： Microscopically, the prominent features of Mikulicz disease were acinar atrophy and lymphoid tissue hyperplasia. Immunohistochemical staining showed that the lymphoid tissue was composed of a mixed population of B and T lymphocytes and about 80% of patients were IgG4 positive. Conclusion： Mikulicz disease is an autoimmune disease and mostly occurred in postmenopausal women. Postoperative recurrence may happen. Immunosuppressive agents may be helpful in treatment.