急性心肌梗死患者生长分化因子-15与梗死面积及相关梗死标志物水平相关性研究

Study on the relationship between figures of GDF-15 with the area of acute myocardial infarction and relative indicators

目的探讨生长分化因子15(GDF-15)与心肌梗死面积及相关指标之间的关系。方法 40例急性心肌梗死(AMI)患者按心肌梗死面积分为大面积组11例(27.5%)、中面积组15例(37.5%)和小面积组14例(35.0%)。另选同期经过冠脉造影证实冠状动脉正常40例为对照组。分别测定各组GDF-15、肌酸激酶MB同工酶(CK-MB)肌酸激酶(CK)、肌钙蛋白I(cTnI)水平,并观察GDF-15与心肌梗死面积及其余指标之间的相关性。结果 AMI各组中的GDF-15的水平明显高于对照组,其浓度的大小随着梗死面积的扩大而变大,而且GDF-15与CK、CK-MB、cTnI及梗死面积具有良好的相关性(r=0.47、r=0.639、r=0.647、r=0.717)。结论 GDF-15对AMI的严重程度的判断和预后估计有重要意义,有可能成为一个新生的生物标志物。

Objective To explore the relationship between changes in figures of growth differentiation factor- 15（ GDF- 15） with the area of acute myocardial infarction and relative indicators. Methods Among 40 patients with acute myocardial infarction,patients with large area of infarction were 11 cases（ 27. 5 %）,patients with median area of infarction were accounted for 37. 5%（ 15 cases）,and patients with small area of infarction accounted for 35%（ 14 cases）,and 40 cases with normal coronary artery confirmed by coronary angiography were allocated in control group. The numerical value of GDF- 15,levels of creatine kinase- MB（ CK- MB）,creatine kinase（ CK） and cardiac troponin I（ cTnI） were applied to observe the correlation between GDF- 15 with size of myocardial infarction and other related indicators. Results The level of GDF-15 in AMI group was significantly higher than that of control group,and its level was elevated with the increase of area of infarction. The figures of GDF- 15 were positively correlated with levels of CK,CK- MB,cTnI and the area of myocardial infarction（ r = 0. 47,r = 0. 639,r = 0. 647,r = 0. 717）. Conclusion The figures of GDF- 15 have important significance in the indication for the severity of AMI and estimation for prognosis,hence it may possibly become a new biological marker.