前列腺素E1联合低分子肝素钙对慢性肺源性心脏病患者肺动脉压和相关生化指标的影响

Effects of PGE1 combined with low-molecular-weight heparin calcium on pulmonary artery pressure and related biochemical indexes in patients with chronic pulmonary heart disease

目的探讨前列腺素E1联合低分子肝素钙对慢性肺源性心脏病患者肺动脉压和相关生化指标的影响。方法选取2013年9月至2015年9月共收治的84例经诊断为慢性肺源性心脏病的患者,按照数字随机分组法将其分为对照组和观察组,每组42例。观察组给予静脉滴注前列腺素E1和皮下注射低分子肝素钙进行治疗,对照组仅给予静脉滴注静脉滴注前列腺素E1进行治疗,共1周。测定并比较两组患者肺动脉压、血浆神经递质内皮素(ET)、血栓素B2(TXB2)、6-酮-前列腺素Flα(6-K-PGFLα)、总胆红质、天门冬氨酸氨基转移酶和尿素氮的含量。结果经治疗后,观察组患者的肺动脉平均压(MPAP)、肺动脉收缩压(PASP)及肺动脉舒张压(PADP)与显著低于对照组(P<0.05);观察组与对照组患者6-K-PGFLα的含量无显著性差异(P>0.05),观察组患者的血浆ET、TXB2、总胆红质、天门冬氨酸氨基转移酶和尿素氮含量均低于对照组(P<0.05)。结论前列腺素E1联合低分子肝素钙的应用可以有效改善慢性肺源性心脏病患者的肺动脉压,对血浆内ET、TXB2、总胆红质、天门冬氨酸氨基转移酶和尿素氮起到良好的调节作用。

Objective To investigate the effect of PGE1 combined with low molecular weight heparin on pulmonary artery pressure and related biochemical indexes in patients with chronic pulmonary heart disease. Methods 84 patients diagnosed as chronic pulmonary heart disease from September 2013 to September 2015 were divided into the control group and the observation group according to the digital random grouping method,42 cases in each group. The observation group was given intravenous injection of PGE1 and subcutaneous injection of low molecular weight heparin calcium treatment. The control group only received intravenous infusion of PGE1 for treatment. Treatment time was a week. To determine and compare the two groups of patients with pulmonary arterial pressure,plasma neurotransmitter endothelial（ ET） and thromboxane B2（ TXB2）,6- keto- prostaglandin F1 alpha（ 6- K- PGFL alpha）,total bile red,aspartate aminotransferase and urea nitrogen concentration. Results After treatment,the mean pulmonary artery pressure（ MPAP）,pulmonary artery systolic blood pressure（ PASP） and diastolic blood pressure（ PADP） of the patients in the observation group were significantly lower than those in the control group（ P〈0. 05）. There was no significant difference between the control group and the observation group（ P〉0. 05）（ 6- K- PGFL）. The observation group of patients with plasma ET,TXB2,total bilirubin,aspartate aminotransferase and urea nitrogen contents were lower than the control group（ P〈0. 05）. Conclusion Application of PGE1 combined with low molecular weight heparin calcium can effectively improve pulmonary artery pressure in patients with chronic pulmonary heart disease. They can adjust the concentration of plasma ET,TXB2,total bilirubin,aspartate aminotransferase and urea nitrogen.