利湿消肿汤治疗股骨头坏死骨髓水肿临床研究

Clinical Research on Lishi Xiaozhong Tang in Treating Osteonecrosis of the Femoral Head with Bone Marrow Edema

目的:观察利湿消肿汤治疗股骨头坏死骨髓水肿湿蕴结证的临床疗效。方法:将180例(315髋)股骨头坏死伴骨髓水肿湿热蕴结证患者随机分为3组,每组60例,治疗组口服利湿消肿汤加丹郁骨康丸治疗,对照组Ⅰ采用丹郁骨康丸、复方丹参注射液和七叶皂甘钠片治疗,对照组Ⅱ采用丹郁骨康丸治疗。3组均以3个月为1个疗程,共治疗3个疗程。治疗后比较两组患者临床疗效和不良反应。结果:治疗组有效率为91.84%,对照组Ⅰ有效率为60.40%,对照组Ⅱ有效率为55.34%。治疗组与对照组Ⅰ疗效、对照组Ⅱ比较,差异有显著差异(P<0.05);对照组Ⅰ疗效与对照组Ⅱ比较,差异有显著差异(P<0.05)。结论:利湿消肿汤治疗股骨头坏死骨髓水肿湿热蕴结证疗效显著。

Objective： To evaluate the effects of Lishi Xiaozhong Tang in treating accumulation type of osteonecrosis of the femoral head with bone marrow edema. Methods： 180 cases（ 315 hips） with bone marrow edema were randomly divided into 3 groups,60 cases in each group. Patients in treatment group was given oral Lishi Xiaozhong Tang and Danyu Gukang Pill treatment,the control group Ⅰ was given Danyu Gukang Pill combined with intravenous drip of compound Salvia miltiorrhiza injection,and Seven sodivm aescine treatment,the control group Ⅱ was given Danyu Gukang Pill. Results： The effective rate of treatment group was 91. 84%,the control group Ⅰ was 60. 40%,the treatment group compared with the controlⅠandⅡgroups showed that the difference was statistically significant（ P〈0. 05）; Control groupⅠcompared with control group Ⅱ showed that there was a statistically significant difference（ P〈0. 05）. Conclusion： The clinical curative effect of Lishi Xiaozhong Tang in treating accumulation type of osteonecrosis of the femoral head with bone marrow edema is obvious.