金樱子根三萜类的化学成分研究

Triterpenoids from roots of Rosa laevigata

目的研究金樱子Rosa laevigata根中的化学成分。方法利用各种色谱柱对金樱子根中的化学成分进行分离纯化,并根据理化性质和光谱分析进行结构鉴定。结果从金樱子根的二氯甲烷及醋酸乙酯部位中分离得到13个三萜类成分,分别鉴定为niga-ichigosides F2（1）、野蔷薇亭（2）、阿江榄仁亭（3）、构莓苷F1（4）、蔷薇酸（5）、号角树酸3-甲酯（6）、2-乙酰基-洋委陵菜酸（7）、坡模酸（8）、2α,3α-二羟基乌苏-12,18-二烯-28-酸（9）、3β-E-feruloyl corosolic acid（10）、覆盆子酸（11）、2-O-乙酰基野鸭椿酸（12）、12,13-dihydromicromeric acid（13）。结论化合物3、6、7、9～13为首次从该植物中分离得到;化合物10、12、13为首次从蔷薇属中分离得到。

Objective To study the triterpenoids from the roots of Rosa laevigata.Methods The silica gel column chromatography was used to extract and separate the chemical constituents from the roots of R.laevigata.HPLC was used to analyze its purity,chemical and spectroscopy methods were used to determine their structures.Results Thirteen constituents were isolated and identified as niga-ichigosides F2（1）,rosamultin（2）,arjunetin（3）,kaji-ichigoside F1（4）,auscaphic acid（5）,cecropiacic acid 3-methyl ester（6）,2-acetyl tormentic acid（7）,pomolic acid（8）,2α,3α-dihydroxyurs-12,18-dien-28-oic acid（9）,3β-E-feruloyl corosolic acid（10）,fupenzic acid（11）,2-O-acetyl euscaphic acid（12）,and 12,13-dihydromicromeric acid（13）.Conclusion Compounds 3,6,7 and 9—13 are obtained from this plant for the first time.Compounds 10,12 and 13 are obtained from the plants of Rosa L.for the first time.