他汀类药物对中国老年脓毒症患者住院期间病死率的影响

Effect of statins on in-hospital mortality in elderly Chinese patients with sepsis: a retrospective cohort study

目的探讨他汀类药物对中国老年脓毒症患者住院病死率的影响。方法对212例2009年3月至2012年3月在浙江大学医学院附属第一医院老年科住院的老年脓毒症患者进行研究。以出院为观察终点,将患者分为死亡组和存活组。采用多因素Logistic回归模型分析,以确定应用他汀类药物是否为住院期间病死率的的独立影响因素。结果存活组使用他汀类药物的患者比例高于死亡组[13.9%（5/36）vs.34.7%（61/176）,χ^2=6.014,P=0.014],调整后的比值比（OR）有统计学意义（OR：0.17;95%CI：0.04-0.85;P=0.03）。结论他汀类药物的使用可能可以降低中国老年脓毒症患者住院期间的病死率。

Objective To investigate the prognostic value of statins on elderly Chinese patients with sepsis. Methods A total of 212 elderly Chinese patients with sepsis hospitalized in First Affiliated Hospital, Zhejiang University School of Medicine, from March 2009 to March2012 were enrolled into the study. Time to discharge from the hospital was selected as the primary endpoint. All the patients were divided into the death group and survival group, and the variables were compared between the two groups. The multivariate logistic regression was applied to assess the independent risk factors for death among the patients during the hospitalization. Results The proportion of the patients treated by statins continuously in the death group was significantly higher than that in the survival group [13.9%（5 / 36） vs. 34.7%（61 / 176）, χ^2= 6.014, P = 0.014], and the statins were the independent predictor for death during hospitalization（OR： 0.17; 95%CI： 0.04- 0.85; P = 0.03）. Conclusion Statins may reduce the inhospital mortality in elderly Chinese patients with sepsis.