Wolffian附件肿瘤3例并文献复习

Female Wolffian adnexal tumor: three cases report and review of the literature

目的探讨Wolffian附件肿瘤(Wolffian adnexal tumor,WAT)的临床病理学特征、鉴别诊断及其预后。方法对3例WAT进行临床病理学观察和免疫组化标记,并复习相关文献。结果 3例患者年龄分别为25、49及55岁,肿瘤分别位于后腹膜、左侧输卵管系膜及右侧卵巢。镜下肿瘤细胞呈弥漫实性或筛网状分布,弥漫实性区可见成片稍肥胖的梭形或卵圆形细胞及紧密排列的管状结构,管腔内衬立方或柱状上皮;瘤细胞无明显异型,核分裂罕见;管周有PAS阳性的基膜样物质。免疫表型:3例瘤细胞CKpan、vimentin、Calretinin均阳性,CD99阳性1例,α-inhibin阳性2例,PR、CK7、EMA均阴性。结论 WAT是一种罕见的具有低度恶性潜能的肿瘤,需进行长期密切随访。

Purpose To investigate the clinical pathological characteristics, differential diagnosis and prognosis of Wolffian adnexal tumor （WAT）. Methods Three cases of WAT were studied clinically, histopathologitally with immunohistohemieally and the related literatures were also reviewed. Result Cases occurred in female and the age of patients ranged from 25, 49 to 55. The tumors were located in the retroperitoneum, left mesosalpinx and right ovary. The tumour cells were arranged in diffuse or solid sheets and reti- forms, with closely packed tubular formation in the solid sheets. The tubes were lined by cubical epithelial or columnar epithelia. The tumor cells were spindle or polygonal with no obvious atypia and mitotic figures were rare. Basement membrane was positive for PAS. Immunohistochemieally, the tumor cells were positive for CKpan, vimentin, Calretinin. There was 1 positive for CD99, 2 positive for a-inhibin. All of case were nagative for PR, CK7 and EMA. Conclusion WAT is a rare tumor with low malignant potential and should be under close and long-time follow up.