胃癌患者术前预后营养指数与辅助化疗效果及预后的关系

Relationship between preoperative prognostic nutritional index and the effect of adjuvant chemotherapy and prognosis in patients with gastric cancer

目的探讨胃癌患者术前预后营养指数(prognostic nutritional index,PNI)与辅助化疗效果及预后的关系。方法回顾性分析本院2009年6月至2012年6月行胃癌根治术并经病理确诊的80例患者的临床资料。根据患者术前1周的检查结果计算PNI,探讨PNI与患者辅助化疗效果及预后的关系。结果 80例患者平均PNI为45.8±11.9,随访期间死亡12例,PNI高的患者死亡率低于PNI低的患者,且PNI高的患者辅助化疗不良反应发生率低于PNI低的患者(P<0.05)。脉管癌栓(P=0.04)、PNI(P=0.014)、肿瘤浸润深度(P=0.08)是胃癌患者死亡的独立危险因素。结论 PNI高的胃癌患者辅助化疗不良反应发生率及术后死亡率低,PNI是胃癌患者死亡的独立危险因素。

Objective To investigate the relationship between preoperative prognostic nutritional index（PNI） and prognosis in patients with gastric cancer. Method The clinical data of 80 patients with gastric cancer who underwent radical gastrectomy for gastric cancer from June 2009 to June 2012 were analyzed retrospectively. PNI values were calculated according to the results of patients within 1 week before operation, and the relationship between PNI and untoward reactions and prognosis were discussed. Result The average PNI of 80 patients was（45.8±11.9）, 12 patients died, the mortality was higher in patients with high PNI than patients with low PNI（P〈0.05）. Lymphovascular invasion（P = 0.04）, PNI（P = 0.014）, tumor invasion depth（P = 0.08） were the independent risk factors of mortality in patients with gastric cancer. ConclusionPatients with high PNI have less untoward reaction and low mortality, and PNI is the independent risk factor of mortality in patients with gastric cancer.