抗生素联合糖皮质激素治疗儿童重症支原体肺炎的临床效果分析

Clinical effect of antibiotic combined with glucocorticoid in the treatment of children with severe myco-plasma pneumonia

目的探讨抗生素联合糖皮质激素治疗儿童重症支原体肺炎的临床效果。方法将51例重症支原体肺炎患儿根据入院先后顺序分为对照组(25例)与观察组(26例),对照组患儿给予阿奇霉素治疗,观察组患儿在对照组基础上给予地塞米松治疗。比较两组患儿临床疗效、临床症状改善时间、住院时间、治疗前后免疫球蛋白(Ig)及C反应蛋白(CRP)变化情况。结果观察组患儿治疗总有效率明显高于对照组(P<0.05)。观察组患儿临床症状改善时间、住院时间均短于对照组(P<0.05)。两组患儿治疗前IgA、IgM、IgG及CRP水平比较差异均无显著性(P>0.05);治疗后观察组患儿IgA、IgM、IgG水平均高于对照组(P<0.05),CRP水平低于对照组(P<0.05)。结论抗生素联合糖皮质激素治疗儿童重症支原体肺炎能显著改善患儿临床症状,抑制炎性反应,缩短治疗时间,提高患儿免疫力,是一种安全可靠的治疗方式。

Objective To explore the clinical efficacy of antibiotic combined with glucocorticoid in the treatment of children with severe mycoplasma pneumonia. Method 51 children with severe mycoplasma pneumonia were divided into control group（25 children） and observation group（26 children） according to the hospitalization consequence, children in control group were treated by azithromycin, and children in observation group were treated by dexamethasone on the basis of control group. The efficacy, improvement time of clinical symptoms, changes of immunoglobulin（Ig） and C reactive protein（CRP） before and after treatment between the two groups were compared. Result The total effective rate of observation group was significantly higher than control group（P〈0.05）. The clinical symptom improvement time and hospitalization time in observation group were less than control group（P〈0.05）. There were no significant differences in the levels of IgA, IgM, IgG and CRP between the two groups before treatment（P〉0.05）. After treatment, the levels of IgG, IgM and IgA in observation group were all higher than control group（P〈0.05）, and the level of CRP was lower than control group（P〈0.05）. Conclusion Antibiotic combined with glucocorticoid in the treatment of children with severe mycoplasma pneumonia can significantly improve clinical symptoms, inhibit inflammation reaction, shorten the treatment time and improve the immunity of children, it is a safe and reliable treatment method.