影响体外受精-胚胎移植结局的职业、学历及居住地因素分析

Occupational, educational and residential factors are associated with the outcomes of in vitro fertilization-embryo transfer

目的探讨体外受精-胚胎移植（IVF-ET）结局与患者职业、学历及围孕期居住地的关系。方法回顾南方医院生殖中心2010年1月~2014年6月首次IVF-ET助孕患者（n=3998）以及同期所有围产儿临床资料（n=3064）。了解不同IVF-ET结局与患者职业、学历及居住地的关系。结果与本中心总体水平相比,女方务农患者早期流产风险升高（OR=4.319,P=0.047）。男女双方职业与学历与IVF-ET异位妊娠存在相关性。围产儿出生缺陷发生率为2.1%。深圳市出生缺陷发生率较高（5.5%）,但与广东省其他地区差异无统计学意义（P〉0.05）。结论患者职业及学历对IVF-ET助孕结局有一定影响。积极开展卫生宣教和产前检查十分必要。

Objective To investigate the associations of occupational, educational and residential factors with the outcomes of in vitro fertilization-embryo transfer（IVF-ET）. Methods A retrospective analysis was conducted among 3998 patients undergoing the first treatment with IVF-ET and 3064 perinatal infants in our center between January, 2010 and June, 2014. The relation of the patients＇ occupation, educational background, and residence registry with IVF- ET outcomes was analyzed. Results The risk of abortion in the first trimester was significantly higher in female patients engaged in agriculture（OR=4.319, P=0.047）.Occupation and educational background of the patients and their spouse were related with the incidence of ectopic pregnancy following IVF-ET. The total incidence rate of perinatal birth defects was 2.1% in this cohort, and was the highest in Shenzhen（5.5%） but this difference was not statistically significant（P0.05）. Conclusion The patients＇ occupation and educational background are related with the outcomes of IVF-ET, suggesting the importance of health education and prenatal examination.