肥胖与偏头痛发病相关性的meta分析

A meta-analysis of the correlation between obesity and migraine

目的探究肥胖是否与偏头痛发病存在相关性。方法按照Cochrane系统评价的方法,通过计算机检索Pub Med,EMBASE英文数据库以及万方、中国期刊全文数据库（CNKI）、中国生物医学数据库,收集所有研究肥胖与偏头痛发病相关性的文献。使用Stata12.0软件进行meta分析,采用比值比（OR）和95%可信限（CI）评估肥胖和偏头痛发病的相关性。结果共纳入14个研究,包含193274个研究对象。meta分析结果显示,肥胖人群对比体质量正常人群,偏头痛发生风险增加19%（OR,1.19;95%CI,1.02~1.38;P=0.029）,肥胖人群对比非肥胖人群,偏头痛发生风险增加19%（OR,1.19;95%CI,1.02~1.38;P=0.024）。结论肥胖与偏头痛发病存在相关性,肥胖人群偏头痛发病风险升高。

Objective To explore the relationship between obesity and migraine. Methods The online databases inlcuding Pub Med, EMBASE, Wanfang, CNKI and Chinese Biological Medicine Database were searched for studies assessing the relationship between obesity and migraine according to the Cochrane Collaboration guidelines. Stata12.0 software was used for meta- analysis. Odds ratios（ORs） with 95% confidence intervals（CIs） were used to assess the relationship between obesity and the risk of migraine. Result A total of 14 studies involving 193 274 individuals were included in the analysis. The results of meta- analysis showed that obese individuals had an increased risk of migraine by 19% as compared with normal weight individuals [OR, 1.19; 95%CI, 1.02-1.38; P=0.029） and by 19% as compared with non-obese individuals（OR, 1.19; 95%CI, 1.02-1.38; P=0.024）. Conclusion Obesity is associated with an increased risk of migraine.