辛伐他汀联合氯吡格雷对不稳定型心绞痛患者血清炎症因子及预后的影响研究

Study of the influence of serum inflammatory factors and prognosis in patients with unstable angina pectoris treated with simvastatin combined with clopidogrel

目的探讨辛伐他汀、氯吡格雷联合治疗不稳定型心绞痛患者对其血清IL-6、hs-CRP水平及患者预后的影响。方法选择2012年6月~2015年1月期间就诊于我院心内科的不稳定型心绞痛患者作为研究对象共120例,随机分为观察组和对照组各60例。对照组患者给予辛伐他汀药物治疗,观察组患者给予辛伐他汀联合氯吡格雷治疗。对两组患者的临床治疗效果及血清IL-6、hs-CRP水平、出院后1个月内心血管事件发生情况进行比较分析。结果与治疗前相比,治疗后两组患者血清hs-CRP、IL-6水平显著降低,差异具有统计学意义（P〈0.05）;且治疗后观察组患者血清hs-CRP、IL-6水平显著低于对照组,差异具有统计学意义（P〈0.05）。两组患者治疗总有效率比较差异具有统计学意义（P〈0.05）。观察组患者出院后30 d内心绞痛再发率（3.33%）、心肌梗死率（1.67%）显著低于对照组（15.00%、10.00%）,差异具有统计学意义（P〈0.05）。结论辛伐他汀联合氯吡格雷治疗不稳定型心绞痛可以显著减低患者血清IL-6、hs-CRP水平,减轻炎症反应,提高治疗效果,改善患者预后。

Objective To investigate the influence of IL-6, hs-CRP and prognosis in patients with unstable angina pectoris treated by simvastatin combined with clopidogrel. Methods A total of 120 patients with unstable angina in the department of cardiology of our hospital from Jun 2012 to Jan 2015 were selected as research objects, they was randomly divided into the observation group and the control group, 60 cases in each group. The control group was treated with simvastatin, the observation group was treated with simvastatin combined with clopidogrel. The clinical therapeutic effect and serum levels of IL-6, hs-CRP and occurrence of cardiovascular events in one month after discharge of two groups were compared. Results After treatment, the levels of hs-CRP and IL-6 in two groups were significantly decreased compared with before treatment, the difference was statistically significant（P〈0.05）; The levels of hs-CRP and IL-6 in the observation group were significantly lower than those of the control group, the difference was statistically significant（P〈0.05）. The total effective rates of two groups had statistically significant difference（P〈0.05）. The angina recurrent probability（3.33%） and myocardial infarction risk（1.67%） of observation group within 30 days were significantly lower than that of the control group（15.00%, 10.00%）, the difference was statistically significant（P〈0.05）. Conclusion In the treatment of unstable angina, simvastatin combined with clopidogrel can significantly reduce the levels of IL-6 and hs-CRP, reduce the inflammatory reaction, improve the treatment effect and the prognosis of patients.