基层医院76例乳腺肿块细针穿刺细胞学与组织病理学对照分析

Comparative analysis of fine needle aspiration cytology and histopathology in the diagnosis of breast masses in primary hospital

目的探讨细针穿刺细胞学在基层医院乳腺良恶性肿瘤诊断中的准确率及误诊率。方法收集本院2011年7月~2014年7月以来乳腺细针穿刺细胞学检查的患者76例,进行细胞学和组织病理学结果对比分析。结果76例乳腺肿块的细胞学与组织病理学诊断对照分析,统计学结果显示：细胞学检查诊断的准确性与组织学诊断的准确性差异无统计学意义（P〉0.05）。细胞学诊断符合率94.74%,对恶性肿瘤诊断敏感性为93.10%,对良性病变诊断特异性为95.74%,假阴性率（漏诊率）为6.90%,假阳性率（误诊率）为0%,潜在假阳性率为4.26%。结论穿刺针吸细胞学检查具有安全、经济、痛苦小、微创、准确率较高等优点,在基层医院值得大力发展;同时FNAC也存在一定局限性,需要结合组织病理学诊断,提高乳腺肿块良、恶性诊断的准确率。

Objective To evaluate the accuracy and misdiagnosis of fine needle aspiration cytology（FNAC） in diagnosis of breast masses in primary hospital. Methods A total of 76 FNAC cases of breast masses from July 2011 to July 2014 were performed and checked with their histopathologic diagnosis. Results A comparison analysis had been made between the fine needle aspiration cytologic diagnosis and the histopathologic diagnosis, the difference was not statisti cally significant（P〉0.05）, which showed that there was no difference between the accuracy of cytological diagnosis and histological diagnosis. The diagnose accordance rate was 94.74%. The sensitivity of diagnosis of malignant tumor and the specificity of diagnosis of benign lesion were 93.10% and 95.74% respectively. The false negative rate, false positive rate and potential false positive rate were 6.90%, 0% and 4.26% respectively. Conclusion The needle aspiration cytology is safe, economical, less pain, minimally invasive and high accuracy rate, etc, should be vigorously developed in the primary hospital; at the same time it has certain limitations, it can improve the diagnosis of pathological changes in breast masses when combined with histopathology.