戊酸雌二醇联合米非司酮在妊娠中期引产中的应用

Application of estradiol valerate combined with Mifepristone of the labor induction in second trimester

目的探讨戊酸雌二醇（补佳乐）联合米非司酮、米索前列醇片在妊娠中期引产中的应用价值。方法选取我院妇产科2013年1月~2014年1月适合条件要求引产的孕中期产妇156例,随机筛选80例分为观察组,即戊酸雌二醇（补佳乐）联合米非司酮片口服2 d后加用米索前列醇片引产,其余76例为对照组,进行常规米非司酮片口服2 d后加用米索前列醇片引产,进行比较。结果观察组引产率97.50%成功率高于常规组85.53%,差异有统计学意义（P〈0.05）。规律宫缩开始,产程进展观察组（3.85±1.22）短于对照组（4.55±1.25）（P〈0.05）。观察组疼痛感低于对照组（P〈0.05）。引产后观察组宫腔残留率21.25%低于对照组39.47%（P〈0.05）。结论戊酸雌二醇（补佳乐）联合米非司酮、米索前列醇片在妊娠中期引产中提高了引产成功率,缩短了产程,减轻了产妇的疼痛感,产宫腔残留降低。

Objective To study the application value of estradiol valerate（Bu Jiale） combined with mifepristone and misoprostol in the labor induction. Methods A randommized caomparative study in 156 cases of the second trimester＇women who were selected in the department of obstetrics in our hospital in January 2013 to January 2014 was conduted, and were randomly divided into observation group, 80 cases, who were induced labor through using misoprostol after they oral estradiol valerate（progynova） combined with mifepristone in two days. Two days, the control group of 76 cases were induced labor through using misoprostol after they were conventional mifepristone, then compare two groups. Results The successful induction rate of the observation group was higher than that of the control group（P〈0.05）. The progress of the observation group was faster than that Control group in rules of uterine contraction（P〈0.05）; the pains of the observation groups was lower than that control group（P〈0.05）. After induction of the intrauterine residue, The observation groups was lower than that of the control group（P〈0.05）. Conclusion The key of combined with mifepristone and misoprostol are to raise the successful rates of the induced labor, and then shorten the birth process, estradiol valerate（progynova） in induced labor of middle pregnancy improves, reducing maternal pain, uterine cavity reduces.