丙酸氟替卡松对哮喘预测指数阳性婴儿的治疗价值

Therapeutic value of fluticasone propionate on infants with positive asthma predictive index

目的探讨丙酸氟替卡松对哮喘预测指数阳性婴儿的治疗价值。方法将我院诊断为哮喘预测指数阳性婴儿分为干预组和对照组各40例,干预组接受丙酸氟替卡松预防治疗,对照组不接受治疗干预。对比两组治疗6、12个月时平均喘息发作次数,两组患儿5岁时进行回访,计算两组患者哮喘诊断率。结果两组治疗6、12个月的平均喘息发作次数比较,差异有统计学意义(P<0.05)。两组哮喘诊断率分别为10.0%、37.5%,差异有统计学意义(P<0.05)。结论丙酸氟替卡松能明显减少患儿喘息发作次数,且不干扰患儿的生长发育。

Objective To investigate the therapeutic value of fluticasone propionate on infants with positive asthma predictive index. Methods Infants who were diagnosed to be positive asthma predictive index were selected and divided into two groups with 40 cases in intervention group and 40 cases in control group. Infants from intervention group received preventive treatment with fluticasone propionate and infants from control group received no preventive intervention. Average onset frequency of asthma of 6 months and 12 months of intervention group and control group was compared. Follow-ups of the two groups were performed at the age of 5 years old and diagnostic rate of asthma and body height were calculated. Results Diagnostic rate of asthma of intervention and control group was 10.0% and 37.5% respectively with significant statistical differences（P〈0.05）. Conclusion Fluticasone propionate is thought to decrease onset frequency among infants with asthma without interfering the development of infants.