盐酸多奈哌齐在老年痴呆治疗中的应用分析

Analysis of Donepezil Hydrochloride Application in Treatment of Senile Dementia

目的探究老年痴呆患者采用盐酸多奈哌齐治疗的方法和效果。方法选取2014年7月~2015年11月收治的58例老年痴呆患者进行治疗,随机分组,实验组33例患者接受盐酸多奈哌齐的治疗,对照组25例患者给予常规治疗,比较患者日常生活能力等恢复情况。结果实验组患者治疗有效率为90.91%,对照组患者治疗有效率为76.0%。实验组患者的治疗效果具有统计学意义（P〈0.05）,且治疗前两组患者在简易精神状况检查评分和日常生活能力表评分中没有差异（P〉0.05）,治疗后实验组患者的评分高于对照组,差异具有统计学意义（P〈0.05）。结论老年痴呆患者采用盐酸多奈哌齐治疗,可使患者的认知能力和日常生活能力得到有效改善,不良反应小。

Objective Treatment method and its effect of donepezil hydrochloride in application of senile dementia are to be studied. Methods Chose 58 patients of senile dementia who were treated in hospital from July 2014 to November 2015 and separated them into two groups at random,33 patients in study group were given donepezil hydrochloride treatment,while another 25 patients in control group were given conventional treatment and then compared patients＇ living ability recovery conditions between two groups. Results Patients＇ treatment efficacy in study group was 90.91%,which was much higher than 76.0% in control group（P〈0.05）,however,there was no differential between two groups before treatment in terms of patients＇ mental state test score and assessment score of daily living activities（ADL）（P〉0.05）,but,patients＇ assessment score in study group were improved much more favorable after treatment compared to patients in control group（P〈0.05）. Conclusion Donepezil Hydrochloride is effective in treatment of senile dementia,it is conducive to improving patients＇ cognition ability and daily living ability with few side effects.