肿瘤细胞坏死因子α和C反应蛋白在大面积脑梗死性癫痫中的动态观察

Dynamic Observation of Tumor Cell Necrosis Factor Alpha and C-reactive Protein in the Epilepsy of Large Area Cerebral Infarction

目的探讨大面积脑梗死性癫痫患者血清中肿瘤细胞坏死因子α和C反应蛋白的动态变化。方法选自2012年1月~2014年1月收治的大面积脑梗死并发癫痫的患者35例（观察组）及35例健康体检者（对照组）。采用酶联反应吸附法分别检测两组患者外周血中同时间点第1、3、5、7、9、11 d时TNF-α和CRP的水平。结果观察组外周血中TNF-α和CRP水平在3、5、7、9、11 d均高于对照组水平（P〈0.05）,TNF-α在第5 d达最高峰,CRP在第7 d达最高峰。第1 d比较两组差异没有统计学意义（P〉0.05）。结论对照组外周血中TNF-α和CRP水平高于观察组提示TNF-α和CRP可能与大面积脑梗死性癫痫发作有相关性,并可能反映出癫痫的严重程度。

Objective To explore the large area cerebral infarction patients with epilepsy serum tumor necrosis factor alpha and dynamic change of CRP. Methods Selected from January 2012 to January 2014,35 patients with large area cerebral infarction complicated with epilepsy（observation group）and 35 cases of healthy physical examination（control group）. Using enzyme-linked reaction adsorption method with time point in the two groups of patients with peripheral blood was detected in 1,3,5,7,9,11 days of TNF alpha and CRP levels. Results The observation group in the peripheral blood of TNF alpha and CRP levels in 3,5,7,9,11 days level were significantly higher than control group（P〈0.05）. Conclusion In the control group in the peripheral blood of TNF alpha and CRP were significantly higher than in observation group,suggest the TNF alpha and CRP might have correlation with large area cerebral infarction onset seizures,and may reflect the severity of epilepsy.