胎儿纤连蛋白(fFN)联合超声宫颈检查预测早产的临床价值

目的探讨阴道分泌物胎儿纤维连接蛋白（fFN）检测联合阴道超声宫颈检查对早产预测的临床价值。方法选择收治的131例有先兆早产症状的孕妇,通过分别单独检测fFN、超声检查宫颈和联合2种方式,随访其妊娠结局,比较各种方式预测早产的临床价值。结果 fFN阳性组分娩率显著高于fFN阴性组,阴道超声检查宫颈阳性组分娩率显著高于宫颈检查阴性组,2组阳性组、阴性组比较差异具有统计学意义（P〈0.05）;两者联合7 d内及14 d内预测早产分娩的敏感性、特异性、阳性预测率、阴性预测率分别为100.0%、83.6%、71.2%、100.0%,及100.0%、88.9%、82.8%、100.0%。结论分别检测fFN及阴道超声检查宫颈均对预测早产有意义,fFN呈阴性的临床预测价值更高。fFN检测联合超声宫颈检查预测7~14 d内早产准确度、敏感度高达100.0%,是预测早产发生的敏感可靠指标,具有显著的临床价值。

Objective Investigate vaginal fetal protein fiber connection joint vaginal ultrasound screening programme（fFN） to predict the clinical value of premature. Methods Choose 131 cases with aura symptoms of premature pregnant women, through testing fFN separately, ultrasound cervical and joint in two ways, follow-up the pregnancy outcome, Through the statistical analysis,compare a variety of ways to predict the clinical value of premature. Results FFN positive births fFN is significantly higher than negative group, vaginal ultrasound cervical positive group had a significantly higher number of cervical check negative group,there were statistically difference （P〈0.05）; both within 7 d prediction of preterm delivery, sensitivity, specificity, positive predictive rate, negative predictive rate was 100.0%, 83.6%, 71.2%, 100.0%; within 14 d sensitivity, specificity, positive predictive rate, when negative rate were 100.0%, 88.9%, 82.8%, 100.0%. Conclusion Respectively fFN detection and vaginal ultrasound cervical is meaningful, to predict premature fFN negative clinical predictive value is higher.FFN detection combined ultrasound screening programme within 7 to 14 d premature forecast accuracy, sensitivity, as high as 100.0%, is sensitive and reliable predictor of preterm birth occurred, has significant clinical value.