地塞米松辅助地佐辛超前镇痛用于腹腔镜胆囊切除术的效果观察

Preemptive Analgesic Effect of Dexamethasone Auxiliary Dezocine on Patients with Laparoscopic Cholecystectomy

目的:探讨地塞米松辅助地佐辛超前镇痛用于腹腔镜胆囊切除术(LC)的临床效果。方法:将80例在全身麻醉下行LC患者随机分为研究组和对照组各40例。麻醉诱导前15min,对照组静脉注射地佐辛0.15mg/kg,研究组静脉注射地塞米松10mg+地佐辛0.15mg/kg。比较两组拔管后5min、15min舒适度评分(BCS)和镇静躁动评分(SAS),记录术后1h、4h、8h视觉模拟评分(VAS)和术后嗜睡、恶心、呕吐、呼吸抑制等不良反应。结果:拔管后5min、15min,研究组BCS评分明显高于对照组(P<0.05),SAS评分显著低于对照组(P<0.05)。研究组术后1h、4h、8hVAS评分显著低于对照组(P<0.05)。研究组术后恶心发生率明显低于对照组(P<0.05)。结论:地塞米松可有效改善地佐辛用于LC的超前镇痛效果。

Objective：To investigate the preemptive analgesic effect of dexamethasone auxiliary dezocine on patients with laparoscopic cholecystectomy（LC）.Methods：80patients with LC were randomly divided into the study group and the control group,40 cases in each group.At 15 min before anesthesia induction,the control group was given intravenous dezocine 0.15mg/kg,the study group received intravenous dexamethasone 10 mg and dezocine 0.15mg/kg.Comfort score（BCS）and sedation agitation scale（SAS）were compared at 5min,15 min after extubation in two groups.Visual analogue scale（VAS）and drowsiness,nausea,vomiting,respiratory depression were recorded at postoperative 1h,4h,8h.Results：BCS scores and SAS scores at 5min,15 min after extubation in the study group were respectively significantly higher and lower than those in the control group（P0.05）.VAS scores at postoperative 1h,4h,8hin the study group were significantly lower than that in the control group（P0.05）.The incidence of postoperative nausea in the study group was significantly lower than that in the control group（P0.05）.Conclusion：Dexamethasone significantly improved the preemptive analgesic effect of dezocine in patients with LC.