奥美拉唑与西沙比利联合治疗反流性食道炎的临床观察

Clinical observation of reflux esophagitis omeprazole and cisapride combination therapy

目的探讨探索奥美拉唑西沙比利与治疗反流性食道炎的临床效果。方法选取2014年2月-2015年8月医院反流性食道炎患者81例。随机分为单用药组40例和联合用药组41例。单用药组仅予奥美拉唑治疗;联合用药组予奥美拉唑与西沙比利联合治疗。比较2组总有效率,不良反应发生率及患者胃黏膜充血消退时间、溃疡愈合时间。结果联合用药组总有效率95.12%明显高于单用药组的75.00%,差异有统计学意义(P<0.05)。联合用药组的胃黏膜充血消退时间、溃疡愈合时间明显较单用药组短,差异有统计学意义(P<0.05)。2组均未出现明显不良反应,2组比较差异有统计学意义(P<0.05)。结论奥美拉唑与西沙比利联合治疗反流性食道炎的临床效果确切,可有效促进临床症状消退,安全性高,值得推广。

Objective To analyze and explore omeprazole and cisapride combination therapy of reflux esophagitis clinical results. Methods 81 cases of patients with reflux esophagitis were divided into single- drug group（ n = 40） and the combination group（ n = 41）,Single drug treatment group received omeprazole alone; combination therapy group received omeprazole and cisapride combination therapy. Comparison of two groups of the total efficiency,the incidence of adverse reactions and gastric mucosal hyperemia subsided,ulcer healing time. Results The combination group the total efficiency of 95. 12%was significantly higher than that of single drug group 75%,the difference was statistically significant（ P 0. 05）. The combination group of gastric mucosal hyperemia subsided,ulcer healing time was significantly higher than single drug group,the difference was statistically significant（ P 0. 05）. The 2 groups had no obvious adverse reaction,there was significant difference between 2 groups（ P 0. 05）. Conclusion The omeprazole and cisapride combination therapy of reflux esophagitis exact clinical effect,can effectively promote regression of clinical symptoms,safe,worthy of promotion.