摘要
目的探讨甲泼尼龙琥珀酸钠(甲强龙)耳后注射治疗伴2型糖尿病突发性聋的临床效果。方法选取2009年1月-2014年1月医院收治的伴2型糖尿病突发性聋行耳后注射给药患者150例,依照患者具体病情分为治疗组80例与对照组70例,2组均予常规治疗。在此基础上,对照组行鼓室内注射地塞米松治疗;治疗组行耳后注射甲基强的松龙治疗。治疗前后均行电测听检查和声阻抗等检查。患者均给予糖尿病饮食,隔日监测血糖,并给予降糖药物治疗。比较2组治疗效果。结果治疗组总有效率93.8%明显高于对照组的75.7%,差异有统计学意义(χ2=8.32,P<0.05)。治疗后2组PTA比较差异有统计学意义(u=3.10,P<0.05)。2组糖尿病及其他并发症的控制情况比较差异无统计学意义(P>0.05)。结论耳后注射甲基强的松龙治疗伴有2型糖尿病突发性聋效果好,操作简单,不良反应小,值得临床推广应用。
Objective Objective To investigate theclinical effect of methylprednisolone ears- after- injection in the treatment of sudden deafness with type 2 diabetes mellitus. Methods 150 cases of sudden deafness with type 2 diabetes were divided into the treatment group 80 cases,the control group of 70 cases. The 2 groups were given conventional treatment. On this basis,the control group were treated with dexamethasone（ intratympanic injection）; Treatment group were treated with methylprednisolone（ ears- after- injection）. Before and after treatment,all the patients were examined with electrical impedance and acoustic impedance. The patients were given a diabetic diet,day blood glucose monitoring,and treated with hypoglycemic medication. Compare the treatment effect of the 2 groups. Results The total effective rate of the treatment group was 75. 7%,significantly higher than that of the control group（ 93. 8%）,the difference was statistically significant（ χ2=8. 32,P 0. 05）. After treatment,the difference of PTA value between the 2 groups was statistically significant（ u = 3. 10,P 0. 05）. There was no significant difference in the control of diabetes mellitus and other complications between the 2 groups（ P 0. 05）. Conclusion The clinical effect of methylprednisolone ears- after- injection in the treatment of sudden deafness with type 2 diabetes mellitus is good,the operation is simple,the adverse reaction is small. Worthy of clinical popularization and application.
出处
《临床合理用药杂志》
2016年第8期7-8,10,共3页
Chinese Journal of Clinical Rational Drug Use
