摘要
MicroRNA(miRNA)是一类真核生物内源性非编码的单链小分子RNA,长约21nt^23nt。越来越多的miRNA在动物细胞和植物组织中发现,这些成熟的小分子RNA是从具有发夹结构的前体miRNA(pre-miRNA)剪切出来,通过与靶mRNA分子互补结合而抑制蛋白翻译或导致mRNA降解,从而调控靶基因的表达。miRNA是一类重要的基因调控子,在机体的基因表达调控、细胞分化和凋亡以及抗病毒防御中发挥重要的作用。深入理解miRNA介导的宿主与病毒之间的相互调节作用,对于阐明病毒的致病机理与制定治疗策略具有深远的意义。
MicroRNA （miRNA） is a kind of eukaryote endogenous non-coding small single-strand RNA with a length of 21-23 nucleotides. A growing number of miRNA were found in animal cells and plant tis- sue. These mature small RNA can regulate the expression of target mRNA, suppress protein translation and cause mRNA degradation through binding with complementary target mRNA, which from precursor miRNA（pre-miRNA） with hairpin. MiRNA is an important gene regulator and play an important role in expression and regulation of organism gene, cell differentiation, cellular apoptosis, and antiviral defense. A- mong them,the deep understanding of miRNA mediated matual adjustment between host and virus,which have far-reaching significance to clarify the virus pathogenic mechanism and treatment strategy.
出处
《动物医学进展》
北大核心
2016年第4期110-114,共5页
Progress In Veterinary Medicine
