P2X_3受体在灼口综合征患者舌组织神经纤维中的表达

P2X_3 receptor expression in lingual nerve fibres of patients with burning mouth syndrome

采用免疫组织化学技术结合图像分析系统检测P2X_3受体在12例灼口综合征(BMS)患者和9例正常对照组的舌组织神经纤维中的表达水平,平均吸光度值分别为0.56±0.29和0.15±0.06(P<0.001);P2X_3受体表达水平与疼痛VAS评分无相关性(R2=0.012)。P2X_3受体参与了BMS患者的慢性疼痛,但与疼痛程度无相关性。

Patients with burning mouth syndrom（ BMS,n = 12） and patients with wisdom tooth removal（ controls,n = 9） were included.Immunohistochemistry and image analysis were used to quantify P2X_3 receptor expression in lingual nerve fibres. A pain history and score were recorded on a visual analogue scale（ VAS） prior to obtaining a lingual biopsy. The value of P2X_3 receptor positive fibres in BMS and control subjects was 0. 56 ± 0. 29 and 0. 15 ± 0. 06 respectively（ P 0. 001）. There was no significant correlation between P2X_3 and VAS scores（ R2= 0. 012）. Increased P2X_3 may play a role in BMS but not correlated with the VAS score.