期刊文献+

非酒精性Wernicke脑病临床特点及MRI表现 被引量:5

Clinical characteristics and MR imaging features of nonalcoholic wernicke encephalopathy
下载PDF
导出
摘要 目的探讨非酒精性Wernicke脑病(WE)病人临床特点及MRI表现。方法回顾性分析经临床证实的10例非酒精性WE病人临床特点及MRI表现。结果胃肠道疾病所致反复呕吐、急性胰腺炎及妊娠剧烈呕吐为主要发病诱因。精神或意识改变为最常见临床表现。10例病人中仅1例为单发病灶,余9例均为多部位受累,病变部位包括双侧丘脑内侧及三脑室周围区(8例)、中脑导水管周围区(7例)、中脑顶盖(6例)、乳头体(4例)、四脑室底(4例)、小脑蚓部(1例)。所有病灶均于T2WI或T2FLAIR上呈对称性高信号。8例行DWI扫描,病灶呈高或稍高信号。1例行MRI增强检查,病灶呈轻度强化。4例于治疗后复查颅脑MRI,均见病灶缩小或消失。结论非酒精性WE的颅脑MRI表现具有特征性,结合病史及临床表现有助于做出早期诊断。 Objebtive To investigate the clinical characteristics and MR imaging features of nonalcoholic Wernicke encephalopathy(WE). Methods We retrospectively reviewed clinical characteristics and MR imaging features of 10 patients with nonalcoholic WE. Results The main predisposing factors included recurrent vomiting as a result of gastrointestinal disease, acute pancreatitis, and hyperemesis gravidarum. The most frequent neurologic finding was change in consciousness or mental status. On the MR images of the 10 patients, single area was involved in one cases, and multiple areas were involved in the remain 9 cases. The locations of lesions included the medial thalami and the periventricular region of the third ventricle(8 patients), the periaqueductal area(7 patients), the tectal plate(6 patients), the mamillary bodies(4 patients), the floor of forth ventricle(4 patients), and cerebellar vermis(1 patients). The findings were symmetric hyperintensity on T2-weighted or fluidattenuated inversion recovery images in all lesions. Eight patients who underwent diffusion-weighted imaging demonstrated increased signal intensities in the affected areas. Contrast medium was administered in one patient, and the lesions showed slight enhancement. Four patients underwent follow-up MRI after therapy, all lesions shrunked or disappeared. Conclusion Nonalcoholic WE has characteristic MRI findings. Combining with clinical characteristics, MR features are useful in early diagnosis.
出处 《国际医学放射学杂志》 2016年第2期103-106,共4页 International Journal of Medical Radiology
基金 国家自然科学基金面上项目(81271564) 卫计委公益性行业科研专项项目(201402019) 天津市自然科学基金重点项目(12JCZDJC23800)
关键词 非酒精性Wernicke脑病 磁共振成像 维生素B1 代谢性脑病 Nonalcoholic wernicke encephalopathy Magnetic resonance imaging Vitamin B1 Metabolic encephalopathy
  • 相关文献

参考文献3

二级参考文献35

  • 1钟春玖,费国强,金莉蓉.颅脑MRI检查在非乙醇中毒性韦尼克脑病诊断中的价值[J].临床神经病学杂志,2005,18(2):100-102. 被引量:37
  • 2朱立,应远峰.非酒精性Wernicke脑病16例临床分析[J].现代中西医结合杂志,2006,15(7):926-927. 被引量:9
  • 3Donnino M W,Vega J,Miller J,et al.Myths and misconceptions of Wernicke's encephalopathy:what every emergency physician should know[J].Ann Emerg Med,2007,50(6):715-721.
  • 4Rugilo C A,Uribe Roca M C,Zurru M C,et al.Proton MR spectroscopy in Wernicke encephalopathy[J].AJNR,2003,24(5):952-955.
  • 5Prensky A L.Wernicke encephalopathy in infants[J].Neuroophthalmology,2005,25(3):167-168.
  • 6Morcos Z,Kerns S C,Shapiro B E.Wernicke encephalopathy[J].Arch Neurol,2004,61(5):775-776.
  • 7Suzuki S,IchijoM,Fujii H,et al.Acute Wernicke's encephalopathy:comparison of magnetic resonance images and autopsy findings[J].Intern Med,1996,35(10):831-834.
  • 8Antunez E,Estruch R,Cardenal C,et al.Usefulness of CT and MRI imaging in the diagnosis of acute Wernicke's encephalopathy[J].AJR,1998,171(4):1131-1137.
  • 9Desjardins P,Butterworth R F. Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy[J].{H}Molecular Neurobiology,2005,(1/2/3):17-25.
  • 10Ogershok P R,Rahman A,Nestor S. Wernicke encephalopathy in nonalcoholic patients[J].{H}AMERICAN Journal OF THE MEDICAL SCIENCES,2002,(2):107-111.

共引文献7

同被引文献42

引证文献5

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部