三种方法治疗男性少弱精症360例及其卫生经济学评价

Three Methods in the Treatment of Male Oligoasthenospermia and Its Health Economics Evaluation for 360 Cases

目的三种方法治疗男性少弱精症的疗效及其卫生经济学评价。方法将由于少弱精症导致的男性不育患者360例按随机数字表法分为3组,西药组118例,中药组121例,中西医结合组121例。各组均治疗90天为1个疗程,对比治疗前后各组患者配偶妊娠率、精子密度、精子活力及精核蛋白变化,并记录其治疗、检查费用。结果治疗一个疗程后,配偶妊娠率、精子密度、精子活动力、精核蛋白变化比较,差异有统计学意义;中西医结合组的成本效果比最低。结论西药、中药、中西医结合治疗方法均可不同程度提高男性不育症患者配偶妊娠率、精子密度和活力,改善精子精核蛋白的相对含量及构成,其中中西医结合治疗方法的成本效果比最优。

Objective To observe the curative effect of three methods in the treatment of male Oligoasthenospermia and its health economics evaluation. Methods 360 cases of male infertility due to the Oligoasthenospermia were randomly divided into three groups. The Western medicine group had 118 cases,traditional Chinese medicine group had 121 cases,and the combination of traditional Chinese and Western medicine group had 121 cases. All groups were treated for 90 days,which was a course of treatment. The changes in the aspects of spouses of patients with pregnancy rate,sperm density,sperm motility and sperm nuclear protein of the three groups before and after treatment were compared. At the same time,the fees of treatment and inspection were recorded. Results After a course of treatment,in the aspects of the spouse pregnancy rate,sperm density,sperm motility and sperm nuclear protein changes,the difference was statistically significant. The cost effectiveness ratio of the combination of traditional Chinese and Western medicine group was the lowest. Conclusions The three treatment methods can improve the observation index that include male infertility in spouses of patients with pregnancy rate,sperm density,motility of sperm protamine,the relative content and form in different extent. The therapy of integrated medicine has the best cost effectiveness ratio.