合并或不合并肺动脉高压的左心衰竭患者血浆N末端B型利钠肽原水平的差异

Differences of Plasma NT-proBNP Level in Patients With Left Heart Failure Combining or not Combining Pulmonary Hypertension

目的：观察左心衰竭合并肺动脉高压患者血浆N末端B型利钠肽原（NT-pro BNP）水平与肺动脉压力的关系。方法：选择左心衰竭患者391例,按是否存在肺动脉高压及肺动脉压力增高程度分为肺动脉压力正常组（n=102）,轻度肺动脉高压组（n=94）,中重度肺动脉高压组（n=195）。检测三组患者血浆NT-pro BNP水平,并行超声心动图检查左心室内径（LVD）、右心室内径（RVD）,以及左心室射血分数（LVEF）。结果：轻度肺动脉高压组、中重度肺动脉高压组血浆NT-pro BNP水平及RVD均高于肺动脉压力正常组,中重度肺动脉高压组高于轻度肺动脉高压组,差异均有统计学意义（P〈0.05~0.001）。三组LVD、LVEF差异无统计学意义（P〉0.05）。结论：左心衰竭合并肺动脉高压患者较肺动脉压力正常患者血浆NT-pro BNP水平明显升高,且随肺动脉压力的升高呈递增趋势。

Objective： To observe the relationship between plasma levels of NT-proB NP and pulmonary hypertension in patients with left heart failure（LHF）. Methods： A total of 391 LHF patients were enrolled in our study, according to pulmonary arterial pressure, the patients were divided into 3 groups： Control group, the patients without pulmonary hypertension, n=102, Mild pulmonary hypertension group, n=94 and Moderate to severe pulmonary hypertension group, n=195. Plasma levels of NT-pro BNP, left ventricular diameter（LVD）, right ventricular diameter（RVD） and left ventricular ejection fraction（LVEF） were examined and compared among 3 groups.Results： Plasma levels of NT-pro BNP and RVD in Mild pulmonary hypertension group and Moderate to severe pulmonary hypertension group were higher than Control group, those indexes in Moderate to severe pulmonary hypertension group were higher than Mild pulmonary hypertension group, P〈0.05-0.001. While LVD and LVEF were similar among 3 groups, P〈0.05.Conclusion： Plasma levels of NT-pro BNP were increased in LHF patients combining pulmonary hypertension, the changing trend elevated with the increased pulmonary hypertension accordingly.