端粒复合体与冠心病的研究进展

Research advances in telomere complex and coronary heart disease

端粒复合体由端粒DNA、端粒相关蛋白、端粒酶共同构成,是维持染色体DNA稳定的重要结构。多种心血管危险因素和不良生活方式均可造成端粒缩短加快,而健康的生活方式及他汀类药物则可减缓端粒缩短。在细胞、动物等研究基础上,多项端粒复合体与冠心病相关的临床研究,阐明了端粒复合体功能失调在冠心病的发生、发展、预后中起到的重要作用。冠心病患者外周血白细胞端粒长度明显缩短,端粒长度短是心血管事件再发的一个独立的危险因素,具有预测心血管事件预后的价值。目前,针对端粒长度缩短与冠心病相关的机制、端粒相关蛋白与冠心病的相关性以及白细胞亚群的研究等方面尚有研究空间。

Telomere complex is composed of telomere DNA, telomere-binding proteins and telomerase,which is an important structure to maintain the stability of chromosome DNA. A variety of cardiovascular risk factors and unhealthy lifestyle can lead to accelerated telomere shortening,and healthy lifestyle and statins can slow down the telomere shortening. On the basis of cell and animal researches,a lot of clinical researchesontelomere complex associated with coronary heart disease have elaborated that the role that telomere complex dysfunction plays in the occurrence,development and prognosis of coronary heart disease. In patients with coronary heart disease,the telomere length in peripheral leukocyte is shortened. A short telomere length is an independent risk factor incardiovascular event recurrence,and has the value topredict the outcome of cardiovascular events. At present,there are fewstudies about the mechanism of telomere length shortening and its relation ofcoronary heart disease,the correlation between telomere-binding proteins and coronary heart disease,and also lack this kind studyin leukocyte subsets.