丙烯醛诱导大鼠脉络膜新生血管的形成（英文）

The formation of rats' choroidal neovascularization induced by acrolein

目的:探讨丙烯醛(AC)诱导大鼠脉络膜新生血管(CNV)的形成。方法:选取远交群大鼠(SD)12只,随机将大鼠分为三组,即空白组,AC诱导4wk组和AC诱导8wk组,其中空白对照组每日200μL新鲜自来水灌胃,实验组为200μL AC溶液(2.5 mg/kg/d)每日灌胃,分为诱导4wk组和8wk组,取材后视网膜组织石蜡包埋,切片及HE染色。结果:空白对照组及AC诱导4wk组均见RPE-Bruch膜连续性完整,未见明显异常;AC诱导8wk组发现RPEBruch膜连续性缺失,脉络膜新生血管长入视网膜神经上皮层内。结论:长期使用AC可以诱导大鼠脉络膜新生血管形成。

AIM： To investigate the-formation of rats＇ choroidal neovascularization （CNV） induced by acrolein. METHODS ：Twelve Sprague-Dawley rats were randomly divided into three groups, Acrolein 20（}~ L （2, 5 mg/kg/d） was poured into the rats＇ stomach for 4wk as acrolein 4wk and for 8wk as acrolein 8wk group, The same volume of fresh water was also done to the rats as the control group, Remove all eye balls and embed into paraffin with HE staining. RESLUTS：The RPE-Bruch membrane was intact with no obvious abnormality in the control group and acrolein 4wk group. Lost in the continuity choroidal neovascularization 8wk. of RPE and the movement of were found in the acrolein CONCLUSION ：The long time use of acrolein can induce the formation of choroial neovascularization in rats.