复方中药治疗慢性丙型肝炎的Meta分析

Role of Compound Chinese Herbal Medicines in Treatment of Chronic Hepatitis C:A Meta-Analysis of Randomized Controlled Trials

目的:评价复方中药对丙型肝炎病毒核糖核酸(HCV-RNA)转阴率、丙氨酸转氨酶(ALT)复常率和天冬氨酸转氨酶(AST)复常率的影响,从而了解复方中药治疗慢性丙型肝炎的临床疗效。方法:检索中国期刊全文数据库、万方医药期刊论文、中文科技期刊全文数据库、Cochrane Library、Pub Med、中国生物医学文献数据库,查找2004年1月至2013年12月发表的关于复方中药治疗慢性丙型肝炎的随机对照研究,评价纳入研究文献的质量,并进行Meta分析。结果:11项随机对照研究纳入分析,共727例患者。Meta分析结果显示,与对照组比较,治疗组在HCV-RNA转阴率[OR=1.73,95%CI(1.19,2.53),P=0.004<0.05],ALT复常率[OR=2.28,95%CI(1.45,3.59),P=0.0004<0.05]方面均优于对照组。在改善AST复常率[OR=2.33,95%CI(0.88,6.20),P=0.09>0.05]方面治疗组与对照组比较,差异无统计学意义。结论:复方中药对慢性丙型肝炎有一定的治疗效果。

Objective： To evaluate the effect of compound Chinese herbal medicines for Chronic Hepatitis C virus infection according to ribonucleic acid of hepatitis C virus（HCV-RNA） negative conversion ratio, alanine aminotransferase（ALT） normalization rate and aspartate aminotransferase（AST） normalization rate. Methods： Randomized controlled trials from January 2004 to December 2013 in multiple data-base（China National Knowledge Internet, Chinese Scientific Journals Full-text Database, Wanfang medical journal papers, Cochrane Library,Pub Med and Chinese Biomedical Literature Database） were reviewed. After assessing the quality of researches,the meta-analysis was carried on. Results： The 11 RCTs consisting of 727 patients were included. Meta-analysis results showed that treatment group can provide better effect than control group on HCV-RNA negative conversion ratio [OR=1.73, 95%CI（1.19,2.53）, P=0.0040.05] and ALT normalization rates [OR=2.28, 95%CI（1.45,3.59）,P=0.0004〈0.05]. There was no statistically significant difference on improving AST normalization rates [OR=2.33,95%CI（0.88,6.20）, P=0.09〉0.05]. Conclusion： Compound Chinese herb medicines showed certain therapeutic effect on chronic hepatitis C.