妊娠女性尿碘和超氧化物歧化物与甲状腺激素的相关性研究

Relations between urinary iodine concentration,superoxide dismutase and thyroid hormone in pregnant women

目的了解妊娠女性碘营养、超氧化物歧化酶(SOD)与甲状腺激素相关性。方法随机选取2014年6月至2015年4月接受产检的妊娠女性380例,收集血液及尿液标本,采用电化学发光法检测甲状腺激素及甲状腺自身抗体水平,采用碘催化砷铈反应原理检测尿碘水平,采用邻苯三酚自氧化法检测SOD水平。结果 380例妊娠女性尿碘中位数为173μg/L,碘营养总体处于碘充足水平。碘充足组与碘缺乏组游离甲状腺素(FT4)、SOD比较差异有统计学意义(P<0.05);碘充足组与碘过量组FT4、促甲状腺激素(TSH)、SOD比较差异有统计学意义(P<0.05)。碘充足组与碘缺乏组、碘过量组甲状腺疾病患病率比较差异有统计学意义(P<0.05)。甲状腺疾病组SOD水平明显低于甲状腺功能正常组(P<0.05)。结论妊娠女性碘营养水平与甲状腺疾病及氧化应激反应密切相关,及时对妊娠女性进行筛查干预可减少和避免不良妊娠结局的发生。

Objective To investigate the relations between iodine nutrition,superoxide dismutase（SOD）and thyroid hormone in pregnant women.Methods A total of 380 pregnant women receiving prenatal examination between June 2014 and April 2015 were randomly chosen.Serum levels of thyroid hormones and thyroid autoantibodies were determined by using electrochemiluminescence method.Urinary iodine concentration was measured based on the catalytic effect of iodine on the As-Ce reaction.SOD activity was determined by using pyrogallol autoxidation method.Results The median urinary iodine concentration in the 380 cases of pregnant women was 173μg/L,indicating overall adequate iodine nutrition of the pregnant women.Free thyroxine（FT4）level and SOD activity were significant different between iodine-sufficient group and iodine-deficient group（P〈0.05）.FT4 level,thyroid stimulating hormone（TSH）level and SOD activity were significant different between iodine-sufficient group and iodine-excessive group（P〈0.05）.Thyroid disease prevalence was significant different between iodine-sufficient group,iodine-deficient group and iodine-excessive group（P〈0.05）.SOD activity was significant lower in group with thyroid diseases than that in group with normal thyroid function（P〈0.05）.Conclusion Iodine nutritional level in pregnant woman could be closely related to thyroid diseases and oxidative stress reaction.Timely screening and intervention could decrease the risk of adverse pregnancy outcome.