突发性耳聋患者眼肌前庭诱发肌源性电位特点

Characteristics of ocular vestibular evoked myogenic potentials in patients with sudden sensorineural hearing loss

目的观察突发性耳聋患者眼肌前庭诱发肌源性电位(oVEMP)的引出率和各参数指标,并探讨其临床诊断价值。方法选取2014年10月到2015年3月诊断为单侧突发性耳聋的患者36例,进行气导短纯音诱发的眼肌前庭诱发肌源性电位检测,分析对比oVEMP的引出率和各参数指标。分别以突聋对侧耳和25名年龄、性别匹配的健康人25例(50耳)为对照,分析前庭功能受损状况。结果突聋组患耳oVEMP引出率为44.4%(16/36),突聋组对侧健耳oVEMP引出率为52.7%(19/36);对照组oVEMP引出率为100%(50/50)。组间对比显示突聋组患耳和对侧耳与对照组oVEMP引出率比较,差异均有统计学意义(P值均<0.05),突聋组患耳和对侧耳oVEMP引出率比较,差异无统计学意义(P>0.05);突聋组患耳、对侧耳、对照组正常耳组间比较,oVEMP的N1潜伏期、P1潜伏期、波间期、振幅等参数差异均无统计学意义(P值均>0.05)。结论突聋患者在耳蜗受损的同时可以伴有椭圆囊及前庭上神经传导功能障碍,这种功能障碍可以通过oVEMP检测进行客观评估。

Objective To report the response rate and characteristics of various parameters of ocular ves- tibular evoked myogenic potentials in patients with sudden sensorineural hearing loss （SSHL）. Methods Thirty six cases of unilateral SSHL examined between October 2014 and March 2015 were included as the study group. Twenty five age-and gender-matched normal subjects were recruited as the control group. Both pa- tients and normal subjects underwent conventional air conduction ocular vestibular evoked myogenic poten- tial （oVEMP） tests in bilateral ears. The results were compared between the affected and contralateral ears and with the normal controls. Results oVEMPs were elicited in 16 affected ears （44.4%）, 19 contralateral ears （52.7%） and 50 normal ears （100%） （P〈0.05）. oVEMP parameters （N1 latency, P1 latcncy, latency intervals and amplitudes） were not significantly different among the groups （P〉0.05）. Conclusions The uncle and superior vestibular nerves may be damaged in SSHL patients. Such damages may be monitored objec- tively by oVEMP examinations.