西藏拉萨地区世居成年藏族居民酒精性肝病患病现状及其影响因素

Prevalence and risk factors of alcoholic liver disease among Tibetan native adults in Lhasa

目的了解西藏拉萨地区世居成年藏族居民酒精性肝病(ALD)患病现状及其影响因素,为采取相应的防控措施提供参考依据。方法于2009年6月—2010年8月采用分层随机抽样方法在西藏拉萨地区抽取的2 178名≥18岁世居藏族居民进行问卷调查、体格检查和腹部B超检查。结果西藏拉萨地区2 178名世居成年藏族居民中ALD患者106例,ALD患病率为4.87%;其中,酒精性肝炎、酒精性脂肪肝、酒精性肝硬化患者分别为67例、34例和5例,分别占ALD患者总数的63.21%、32.08%和4.72%,多因素非条件logistic回归分析结果显示,年龄≥41岁、文化程度初中及以上、居住在农村、吸烟和空腹饮酒是拉萨地区世居成年藏族居民ALD患病的危险因素,女性是拉萨地区世居成年藏族居民ALD患病的保护因素。结论西藏拉萨地区世居成年藏族居民ALD患病率较高,性别、年龄、文化程度、居住地、吸烟和空腹饮酒情况是该地区居民ALD患病的主要影响因素。

Objective To examine the prevalence and risk factors of alcoholic liver disease（ ALD） among native Tibetan adults in Lhasa city. Methods With cluster sampling method,2 178 native Tibetan residents aged 18 years or above were recruited for a survey including questionnaire interview,physical examination,and type-B ultrasound test. Results The overall prevalence rate of ALD among the participants was 4. 87%,with 67 hepatitis cases,34 fatty liver cases,and 5 cirrhosis cases,accounting for 63. 21%,32. 08%,and 4. 72% of all ALD cases,respectively. The results of multivariate unconditionl logistic regression revealed that the risk factors of ALD among the participants were aged 40 years,with the education of junior high school or above,living in rural area,smoking,and alcohol drinking on an empty stomach; while the protective factor was being female. Conclusion The prevalence rate of ALD among native Tibetan adults in Lhasa city was higher than that among residents of other provinces and age,education,living area,smoking,and alcohol drinking on an empty stomach are main risk factors of the disease.