丙氨酰谷氨酰胺对恶性淋巴瘤化疗后口腔炎的临床疗效研究

Clinical study of alanyl glutamine on chemotherapy-induced oral mucositis in patients with malignant lymphoma

目的观察静脉滴注用丙氨酰谷氨酰胺对恶性淋巴瘤化疗后口腔炎的临床疗效。方法 130例接受化疗的恶性淋巴瘤患者分为试验组和对照组,各65例。对照组每天3餐前后及睡前给予12.5%的碳酸氢钠溶液含漱;试验组在对照组的基础上静脉滴注丙氨酰谷氨酰胺20 g·d^(-1),2组均治疗1周。化疗结束后评价口腔黏膜炎的发生率及口腔炎治愈时间。结果试验组口腔黏膜炎发生率为35.38%,显著低于对照组的46.15%(P<0.05)。试验组Ⅲ级口腔黏膜炎愈合时间为(8.25±0.96)d,显著短于对照组的(11.17±1.47)d(P<0.05)。2组用药期间均无药物相关不良反应发生。结论静脉滴注丙氨酰谷氨酰胺联合碳酸氢钠溶液含漱对防治恶性淋巴瘤化疗后口腔炎有一定的临床疗效。

Objective To investigate the clinical efficacy of alanyl glutamine injection on the prevention and treatment of chemotherapy-induced oral mucositis in patients with malignant lymphoma. Methods A total of 130 cases suffering from chemotherapy of malignant lymphoma were divided into treatment group（ n = 65） and control group（ n = 65）.Both groups were given sodium bicarbonate solution gargled. Patients in control group were given 12. 5% sodium bicarbonate solution gargle,3times a day. And patients in treatment group were given alanine glutamine injection 20 g·d（-1）for 1 week on the basis of control group. After the chemotherapy cycle,the incidence of oral mucositis and stomatitis cure time were compared between the two groups. Results The chemotherapy-induced oral mucositis rate were 35. 38% and 46. 15% in treatment group and control group,with statistical difference（ P〈0. 05）. The cure time for grade Ⅲ chemotherapy-induced oral mucositis were（ 8. 25 ± 0. 96）,（ 11. 17 ± 1. 47） d, with statistical difference（ P〈0. 05）. There was no drug related adverse reaction during the treatment. Conclusion Alanyl glutamine injection combined with sodium bicarbonate gargled has a significantly preventive and therapeutic effect on chemotherapy-induced oral mucositis in patients with malignant lymphoma.