维生素D受体基因与血铅水平的meta分析

The relationship of vitamin D receptor gene and blood lead ： a meta-analysis

目的用meta分析方法探讨维生素D受体（VDR）基因多态性与血铅水平的相关性。方法通过检索CNKI、万方数据库、PubMed，检索国内外1979至2015年间发表的有关铅与VDR B／b基因多态性的相关研究，经筛选最终纳入meta分析的文献有10篇，其中有3项研究进行了分组，将其归为不同的研究，总共13项研究。依据血铅浓度的高低，将研究分为普通人群组、低浓度组和高浓度组。用Stata12．0进行meta分析。结果在剔除前，除高浓度组（P〉0．05，I^2=12．7％）外，普通人群组和低浓度组异质性检验均有统计学意义（P〈0．05，I^2=84．2％；P〈0．05，I^2=88．9％），不同VDR基因B／b与血铅水平的差异有统计学意义（P〈0．05）。剔除后，3组均无异质性，且不同VDR基因B／b与血铅水平的差异有统计学意义（P〈0．05），与上述结果相同。结论VDR基因多态性与血铅水平存在相关性，不同VDR基因位点的血铅水平有差异。

Objective The correlation of vitamin D receptor （VDR） gene polymorphism and blood lead level had been in doult, which allowed us to write this article. Methods Relevant studies about the blood lead and VDR B/b gene polymorphism which published from 1979-2015, were searched in multiple bibliographic databases, such as ： CNKI, Wanfang Database, PUBMED. Of the ten references selceted, three were divided into two groups which were classified as different researches, so there were thirteen studies in the recta-analysis. According to the level of blood lead, the studies were analyzed by three groups ： normal group, low dose grou and high dose group. The analysis was performed by stata 12.0 software. Results The blood lead level of VDR B/ b genotype was significantly difference in all the three groups （P〈0.05）, but there were apparent heterogeneity between normal group and low dose group （P〈0.05,I^2=84.2% ;P〈0.05,I^2=88.9%）, except the high dose group （P〉0.05,I^2=12.7% ）; after adjusted, all showed no heterogeneity, and the results were still the same. Conclusion The genotype of VDR may be correlated with blood lead, and the levels of blood lead varied with different genetypes.