补中益气丸与硫酸庆大霉素治疗犬脾虚泄泻证的比较研究

A Comparative Study of the Effect of Bu Zhong Yi Qi Wan and Gentamycin Sulfate for the Treatment of Splenasthenic Diarrhea of Canine

本试验探讨口服补中益气丸对犬脾虚泄泻证的临床治疗效果.24只健康本地犬饲养1周后,灌胃番泻叶水煎剂(3g/kg·体质量,2次/d)人工复制脾虚泄泻证病理模型,造模成功后随机分为3组:补中益气丸组灌胃补中益气丸3g/kg·体质量,2次/d;硫酸庆大霉素组肌肉注射硫酸庆大霉素注射液10 000IU/kg·体质量,2次/d;病理对照组不作任何处理;同时设4头健康犬作为空白对照,造模期间灌胃生理盐水.治愈后测定试验犬三大生理指标、部分血液生化指标及脾脏指数.结果表明:补中益气丸灌胃后第4d治愈率达100%,肌注硫酸庆大霉素治疗后第5d治愈率为87.5%;补中益气丸治愈后白细胞、红细胞、血红蛋白恢复较快,与硫酸庆大霉素治疗组相比较差异不具有统计学意义(p>0.05);脾脏指数和日增质量显著高于硫酸庆大霉素治疗组(p<0.05).说明灌胃补中益气丸治疗犬脾虚泄泻证的效果优于硫酸庆大霉素.

The research was designed to investigate the effect of orally administered Bu Zhong Yi Qi Wan for the treatment of splenasthenic diarrhea in canine.Twenty-four local healthy dogs were administered intragastrically 3g/kg per body weight senna leaf water decoction for 2times each day after breeding a week for pathogenic model of splenasthenic diarrhea.After the model was artificially copied successfully,all the experimental dogs were randomly divided into 3groups：the group of Bu Zhong Yi Qi Wan intramuscularly injected 3g/kg·body weight of Bu Zhong Yi Qi Wan,2times/d;the group of gentamicin sulfate injected10 000IU/kg·body weight of gentamycin sulfate,2times/d;the pathological control group which received no treatment.At the same time,4dogs were used for the blank group administered intragastrically with physiological saline in the period of pathogenic model building.Three main clinical indicators,the number of white blood cells,red blood cells and hemoglobin and spleen index,were detected after curing.The results indicated that the cure rate was 100% after 4-day＇s treatment with Bu Zhong Yi Qi Wan,and87.5% after 5-day＇s treatment with gentamicin sulfate.The number of white blood cells,hemoglobin and red blood cells recovered to normal levels in a short time after the treatment of Bu Zhong Yi Qi Wan and gentamicin sulfate,with no significant differences between the two treatments.However,the average daily gain of body weight and spleen index after the treatment with Bu Zhong Yi Qi Wan were significantly higher than those of the treatment with gentamycin sulfate（p〈0.05）,thus indicating that Bu Zhong Yi Qi Wan has an advantage over gentamycin sulfate for treating splenasthenic diarrhea canine.