雄激素受体、磷酸化蛋白激酶B在三阴性乳腺癌中的表达及意义

Expression and significance of androgen receptor and phosphorylated protein kinase B in triple negative breast cancer

目的探讨雄激素受体（AR）、磷酸化蛋白激酶B（P-PKB）在三阴性乳腺癌中的表达及意义。方法收集2012年3月．2015年3月惠州市中心人民医院收治的乳腺癌患者115例，其中三阴性乳腺癌54例，非三阴性乳腺癌61例。采用免疫组化S-P法检测AR、P—PKB表达。比较三阴性乳腺癌和非三阴性乳腺癌AR、P—PKB表达阳性率，分析三阴性乳腺癌组织中AR和P—PKB表达与临床病理参数的关系。结果三阴性乳腺癌AR阳性表达率明显低于非三阴性乳腺癌（P〈0．05）：三阴性乳腺癌P—PKB阳性表达率明显高于非三阴性乳腺癌（P〈0．05）；三阴性乳腺癌组织中AR的表达与临床分期和淋巴结转移情况呈显著负相关（r=-0．295、-0．311，P〈0．05）；三阴性乳腺癌组织中P—PKB的表达与临床分期和淋巴结转移情况呈显著正相关（r=0．332、0．329，P〈0．05）。结论AR、P—PKB在三阴性乳腺癌的表达具有重要的意义，可以作为预后的重要指标，并有望成为未来治疗三阴性乳腺癌的新靶点。

Objective To investigate the expression and significance of androgen receptor （AR） and phosphorylated protein kinase B （P-PKB） in triple negative breast cancer. Methods From March 2012 to March 2015, in Central Peo- ple＇s Hospital of Huizhou City, 115 patients with breast cancer were selected, among them, 54 cases were triple nega- tive breast cancer, 61 cases were non-triple negative breast cancer. The expression of AR and P-PKB was detected by immunohistochemistry S-P method. The expression of AR, P-PKB, and AR in triple negative breast cancer and triple negative breast cancer tissues were compared, and the relationship between the expression of P-PKB and the clinico- pathological parameters were analyzed. Results AR positive expression rate of triple negative breast cancer was signifi- cantly lower than non-triple negative breast cancer （P 〈 0.05）; P-PKB positive expression rate of triple negative breast cancer was significantly b;gher than non triple negative breast cancer （P 〈 0.05）; AR expression of triple negative breast cancer tissues had a significantly negative correlation with clinical stage and lymph node metastasis （r = -0.295, -0.311, P 〈 0.05）; P-PKB expression of triple negative breast cancer tissues had a significantly positive correlation with clinical stage and lymph node metastasis （r = 0.332, 0.329, P 〈 0.05）. Conclusion AR, P-PKB expression have a great significance in triple negative breast cancer, can be used as an important indicator of prognosis, and they are ex- pected to become new targets in treatment of triple negative breast cancer.