摘要
目的:使用电感耦合等离子质谱仪,建立顷康片中锂、铍、硼、镁、铝、钛、钒、铬、锰、铁、钴、镍、铜、锌、镓、砷、锶、镉、锡、锑、钡、汞、铊、铅和铋共25种元素的测定方法。方法:顷康片经微波消解后,以锗、铟为内标,以灌木枝叶标准药材作为质控标准物质,用ICP-MS法进行测定。结果:结果表明,各元素的线性关系良好,相关系数r≥0.9994,各元素的检出限在0.001~4.447μg·L^(-1),回收率在87.38%~106.44%,相对标准偏差(RSD)≤7.72%。结论:该方法快速、简便、准确,可以用于顷康片中多元素的质量控制。
Objective: To establish a method for the simultaneous analysis of 25 elements in Qingkang Tablets, including Li, Be, B, Mg, Al, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Sr, Cd, Sn, Sb, Ba, Hg,Tl, Pb and Bi. Methods: The samples, digested via microwave, calibrated by internal standard elements such as Ge and In, with bush branches and leaves as the controlled reference standard, were inlet into ICP-MS to analyze the contents of the 25 elements. Results: The detection limits of the 25 elements were in the range of 0.001-4.447 μg·L^(-1). The 25 elements showed good linearity in the selected concentration ranges(r ≥0.9994), with the average recovery from 87.38% to 106.44%, while their RSD were below7.72%. Conclusion: The method is simple, rapid and accurate. It can be used for the quality control of elements in Qingkang Tablets.
出处
《药学与临床研究》
2016年第2期113-116,共4页
Pharmaceutical and Clinical Research
