变应性鼻炎豚鼠动物模型文献研究

Literature Studies on Guinea Pig Models for Allergic Rhinitis

目的:通过对近5年来发表的变应性鼻炎豚鼠造模的相关文献进行检索,并对其研究方法进行总结。方法:以"变态反应性鼻炎"、"过敏性鼻炎"、"枯草热"、"豚鼠"为中文检索词,以"guinea—pig model"、"guinea—pig model"为英文检索词,对万方、维普、中国知网、Pubmed数据库中2010-2015年发表的相关文献进行检索,对所检索文献进行归纳分析。结果:本次筛选文献205篇,纳入文献60篇。致敏药物共3种,致敏方式共6种,造模周期在7—48天不等。其中,最常用的致敏药物为卵清蛋白(OVA)联合(Al(OH)_3,占63%;最常用的致敏方式是单纯滴鼻法,占40%。在造模后评价方面,以主观性评价为主,主观评价占56.7%。结论:目前中医类研究缺乏根据证候造模的标准路径,且变应性鼻炎豚鼠造模药物、方式、评价等各方面形式多样,无统一标准。

The study aimed to summarize the methods of allergic rhinitis model establishment in guinea pig by retrieving published literatures in recent five years.Chinese keywords of ＂allergic rhinitis＂, ＂hay fever＂, ＂guinea pigs＂,and English keywords of ＂guinea-pig model＂ was searched in Wanfang Data,CQVIP Database Research Center,CNKI Database and Pubmed from 2010 to 2015.Two hundred and five literatures were collected.And a final of sixty literatures were included in the analysis.As a result,three drugs for allergic rhinitis and six sensitization methods were found with modeling period ranging from 7 days to 48 days in guinea pig.Among them,the most common drug was ovalbumin sensitization joint aluminum hydroxide,which accounted for 63%of all the included literatures;while the most common way was intranasal sensitization method,accounting for 40%.In modeling evaluation,subjective evaluation was the main method,which accounted for 56.7%.It was concluded that there was no standard method in making animal model based on syndrome differentiation in traditional Chinese medicine（TCM） research currently.In allergic rhinitis guinea pig model,drugs,methods and evaluations were still various without a uniform accepted standard.