替加环素在抗多重耐药鲍曼不动杆菌感染治疗中的作用

Tigecycline treatment of multidrug-resistant Bahamanian infection

目的观察替加环素与碳青霉烯类抗生素在多重耐药鲍曼不动杆菌感染治疗中的效果。方法选取本院2012年1月至2014年12月间80例多重耐药鲍曼不动杆菌感染患者为研究对象,将其按照随机数字表法分为A组与B组,各40例。A组给予替加环素治疗,B组给予碳青霉烯类抗生素治疗,观察两组的临床治疗效果。结果A组治疗总有效率为75.0%,明显的高于B组的60.0%,差异有统计学意义(P<0.05)。治疗前A组和B组WBC、CRP、PCT比较差异无统计学意义(P>0.05);治疗后两组WBC、CRP、PCT均较治疗前有明显的改善,且A组改善程度明显的优于B组,差异有统计学意义(P<0.05)。A组不良反应发生率2.5%;B组不良反应发生率5.0%。两组差异无统计学意义(P>0.05)。结论临床中对于多重耐药鲍曼不动杆菌感染患者给予替加环素治疗效果显著,明显的优于碳青霉烯类抗生素效果,且安全性高,值得临床中应用与推广。

Objective To observe the effect of tigecycline treatment of multidrug-resistant Acinetobacter baumannii infection. Methods 80 patients with multiple drug resistant Acinetobacter Baumannii infection were selected as the research object. According to the random number table method, 80 patients were divided into group A and group B（n=40）. Group A was treated with tigecycline, and group B was treated with cyclosporine. The clinical effect of the two groups was observed. Results The total effective rate of group A was 75.0%, significantly higher than that of group B（60.0%）（P〈0.05）. Before treatment, WBC, CRP and PCT of group A and group B were not significant different（P〉0.05）.After treatment, WBC, CRP and PCT of both groups were significantly improved, while the improvements in group A were significantly better than in group B（P〈0.05）. The incidence of adverse reactions of group A（2.5%） was significantly less than that of group B（5%）（P〉0.05）. Conclusion Tigecycline treatment effect of multidrug-resistant Acinetobacter baumannii infections is significantly better than that of the carbapenem antibiotic. It is safe and worth of clinical application and promotion.