摘要
目的:分析腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)对术后患者免疫炎症反应指标的影响。方法:分析2013年1月至2015年1月收治的88例胆囊结石患者的临床资料,分为观察组(LC,n=46)与对照组(开腹胆囊切除术,n=42)。结果:观察组患者术中出血量、术后排气时间及术后并发症发生率均显著低于对照组,差异有统计学意义(P<0.05)。观察组术后CD4^+、CD8^+淋巴细胞及CD4^+/CD8^+水平均高于对照组(P<0.05)。观察组患者术后3 d CRP及TNF-α水平低于对照组差异有统计学意义(P<0.05)。结论:与传统开腹手术相比,LC可显著降低患者术后免疫炎症反应程度,提高总体疗效。
Objective:The study was aimed to analyze the impact of laparoscopic cholecystectomy on the immune status and inflammation reaction of patients with gallstones.Methods:Clinical data of patients with gallstones from Jan.2013 to Jan.2015 were analyzed.Patients were divided into two groups,the patients who underwent laparoscopic cholecystectomy were selected as Group A(n=46);the patients who underwent open cholecystectomy were selected as Group B(n=42).Results:Blood loss during operation,postoperative exhaust time and rate of complications of Group A were lower than those of Group B patients,the differences were statistically significant(P〈0. 05).In 3 days after surgery,patients in Group A had higher levels of CD4-+,CD8-+ lymph cell and CD4-+/CD8-+than those in Group B,the difference was statistically significant(P〈0. 05).After surgery,patients of Group A had lower levels of CRP and TNF-α than patients of Group B,the difference was statistically significant(P〈0. 05).Conclusions:Compared with traditional open surgery,laparoscopic cholecystectomy for gallstones is more efficient with a lower postoperative immunosuppression and stress response.
出处
《腹腔镜外科杂志》
2016年第2期124-127,共4页
Journal of Laparoscopic Surgery
关键词
胆囊结石病
胆囊切除术
腹腔镜
免疫
炎症
Cholecystolithiasis
Cholecystectomy
laparoscopic
Immunity
Inflammation