长链非编码RNA MEG3对肿瘤细胞调控作用的研究进展

Research advancement of long non-coding RNA MEG3 in regulating tumor cell apoptosis

长链非编码RNA(long non-coding RNA,lnc RNA)是一类长度超过200 nt的不编码蛋白的RNA分子。lnc RNA最初被认为是转录噪音,在近年的研究中发现越来越多功能性的lnc RNA,其重要性才渐渐被阐述。母系表达基因3(materally expressed gene 3,MEG3)是一种由母系印记基因编码的lnc R NA,在对其功能的研究中发现MEG3几乎参与了所有的生理和病理过程,其在多种肿瘤中表现出抑制作用。本文就lnc RNA MEG3对肿瘤细胞调控的作用机制作一综述。

Long non-coding RNAs（lnc RNAs） are defined as RNA transcripts longer than 200 nucleotides which are not transcribed into a protein. In recent years, it was recognized that lnc RNAs are not only transcriptional noise, but have important cellular functions. lnc RNA are implicated in gene regulation through a variety of mechanisms. Maternally expressed gene 3（MEG3） encodes an lnc RNA which was suggested to function as a tumor suppressor. MEG3 almost involved in the physiological and pathological process. Here we review the role of lnc RNA MEG3 in regulation of tumor cells, and discuss the molecule mechanism.