黑素瘤相关微小RNA的研究进展

Melanoma-related microRNAs

微小RNA参与细胞增殖、分化和凋亡是多种恶性肿瘤发生发展的重要调控因子.研究发现,多种微小RNA在黑素瘤中表达异常,其中Let-7家族、微小RNA 137、微小RNA 200c和微小RNA196a等发挥抑癌基因样作用,而微小RNA 221/222、微小RNA 30b/30d、微小RNA 146a、微小RNA 214和微小RNA 182发挥癌基因样作用.黑素瘤相关微小RNA的研究将丰富黑素瘤的分子生物学发病机制,为黑素瘤的早期诊断和治疗提供新的思路.

MicroRNAs （miRNAs）,as an important regulatory factor in development of multiple malignant tumors,take part in cell proliferation,differentiation and apoptosis.Studies have found aberrant expressions of various miRNAs in melanoma.Among these miRNAs,the Let-7 family,miRNA-137,miRNA-200c and miRNA-196a act as tumor suppressor genes,while miRNA-221/222,miRNA-30b/30d,miRNA-146a,miRNA-214 and miRNA-182 act as oncogenes.Studies on melanoma-related miRNAs will enrich knowledge about molecular pathogenesis of melanoma,and provide new ideas for early diagnosis and treatment of melanoma.