CNTN-1表达在肝癌术后早期复发中的预测价值

Predictive value of CNTN-1 expression in early recurrence of hepatocellular carcinoma after hepatectomy

目的探讨神经黏附分子接触蛋白-1(CNTN-1)在原发性肝细胞性肝癌(肝癌)根治术后早期复发中的预测价值。方法应用免疫组化法研究90例肝癌组织和癌旁组组中CNTN-1的表达。分析CNTN-1与肝癌临床病理特征及术后早期复发的关系。结果 CNTN-1在肝癌组织中表达明显高于癌旁组织(P<0.01)。CNTN-1表达与肿瘤直径、有无完整包膜和TNM分期相关(P<0.05)。单因素Logistic回归分析表明CNTN-1、肿瘤大小、有无完整包膜、微血管侵犯、甲胎蛋白(AFP)、Edmondson分级和TNM分期与肝癌根治术后早期复发密切相关;多因素Logistic回归分析表明CNTN-1高表达是肝癌根治术后早期复发的独立危险因素。结论 CNTN-1的高表达是肝癌根治术后早期复发的潜在预测因子。

Objective To investigate the predictive value of CNTN-1 expression in early recurrence of hepatocellu- lar carcinoma （HCC） after hepatectomy. Methods Immunohistochemistry was used to detect the expression of CNTN-1 in tumor tissues and adjacent non - tumor tissues from 90 HCC patients. The relationships of CNTN-1 ex- pression with clinicopathological parameters and early postoperative recurrence were evaluated. Results CNTN-1 expression was significantly higher in tumor tissues than that in adjacent non -tumor tissues （P 〈 0.01 ）. Besides, CNTN-1 expression was significantly associated with tumor size, tumor capsula, and tumor-node-metastasis （TNM） stage. Univariate logistic regression analysis indicated that early postoperative recurrence of HCC was significantly correlated with CNTN-1, tumor size, tumor capsula, vascular invasion, serum AFP, Edmondson grade, and TNM stage. Multivariate analysis identified CNTN-1 was an independent risk factor for early recurrence of HCC after hep- atectomy. Conclusion High expression of CNTN-1 is a potentialpredictive factor for early recurrence of HCC after hepatectomy.