纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展

Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma

多药耐药是肿瘤化疗中的重要难题,多药耐药的机制复杂,目前尚无有效的治疗策略。纳米载药系统具有靶向性、载药种类多样等优点,近年来成为对抗肿瘤多药耐药的递药载体的重要研究方向。对肿瘤抑制的不同机制进行讨论,并对纳米载药系统逆转骨肉瘤多药耐药的研究进展进行综述。

Multidrug resistance（MDR）of tumor cell is the major problem for chemotherapy.However,there is no effective strategy to overcome MDR due to the complicated mechanism.The nano-sized drug delivery system could target to the tumor cell.Moreover,it could delivery different kinds of drugs.Therefore,the nano-sized drug delivery system has become a promising approach to reverse MDR.The nano-sized drug delivery system which is applied to treat the MDR of tumor（osteosarcoma）was summarized and the reverse mechanism was discussed.