利咽合剂治疗慢性咽炎多中心随机对照临床试验

Multicenter Randomized Controlled Clinical Trials of Utilizing Liyan Mixture to Treat Chronic Pharyngitis

目的:观察中药利咽合剂内服、利咽合剂内服联合利咽合剂雾化吸入及利咽合剂内服联合穴位针刺三种方式治疗阴虚血瘀型慢性咽炎的临床疗效。方法:按照药品临床试验管理规范(good clinical practice,GCP)原则,采用多中心、随机对照研究方法进行临床试验。对180例阴虚血瘀型慢性咽炎受试者按接受治疗方式的不同随机分为A、B、C三组,A组予以单纯中药利咽合剂内服,B组予以利咽合剂内服联合利咽合剂水煎液雾化吸入,C组予以利咽合剂内服联合穴位针刺治疗。结果:我们发现利咽合剂内服联合雾化吸入治疗的患者,在改善咽干、咽部烧灼感、咽部黏膜慢性充血、咽部黏膜干燥等方面较另外2组有明显优势(P<0.05);利咽合剂内服联合雾化吸入组在疗效方面显示出明显优势( A=0.5856、 B=0.3942、 C=0.5339)。结论:表明利咽合剂内服与咽局部雾化吸入对阴虚血瘀型慢性咽炎具有确切的治疗作用,值得临床进一步推广。

Objective： To observe the clinical curative effect of traditional Chinese medicine Liyan Mixture orally and Liyan Mixture orally combined with Liyan Mixture atomization inhalation and Liyan Mixture by oral acupuncture treatment of three ways of Yin-deficiency and blood stasis type of chronic pharyngitis. Methods： According to the good clinical practice（ good clinical practice,GCP） principle,a multi center,randomized study method for clinical trials. In 180 cases of Yin-deficiency and blood stasis type chronic pharyngitis subjects according to different randomized treatment for A,B,C three groups,group A was given Chinese traditional medicine Liyan Mixture orally,group B was given Liyan Mixture orally combined with Liyan Mixture atomization inhalation,group C were given Liyan Mixture orally combined with acupoint acupuncture treatment. esults： We found Liyan Mixture orally combined with atomization inhalation in the treatment of patients,in improving the throat,throat burning,pharyngeal mucosa of chronic pharyngeal mucosa hyperemia,drying and other than the other 2groups had obvious advantage（ P〈0. 05）;Liyan Mixture orally combined with atomizing inhalation group in curative effect showed a clear advantage（ A= 0. 5856, B=0. 3942, C= 0. 5339）. Conclusion： The results suggest that the pharynx preparation oral and pharyngeal local atomization inhalation has definite therapeutic effect on Yin-deficiency and blood stasis type chronic pharyngitis,is worthy of further promotion.