精神分裂症患者脑白质纤维扩散张量成像测量方法研究

An imaging measurement study on the diffusion tensor tractography of white matter fibers in the brains of schizophrenia patients

目的探讨用MR扩散张量成像（DTI）对精神分裂症患者脑白质纤维测量方法研究和意义。材料与方法对10~50岁精神分裂症住院患者（研究组）和50名健康人群（对照组）扩散张量成像脑白质纤维形态和量的分析。结果 （1）比较研究组与对照组年龄和性别无显著统计学意义;（2）比较对照组和研究组各部位对应左右差值分布差异有显著统计学意义（P〈0.05）,发现研究组双侧颞上回、双侧外囊中部及双侧海马钩回左右FA差值明显低于对照组,差值越大,越有统计学意义。结论用扩散张量成像对精神分裂症患者脑白质测量FA值时,取连续相邻两个层面最清晰部位进行对称性测量,发现脑白质某部位扩散张量成像FA值异常,进行左右FA值（胼胝体除外）比较分析时,用左减右FA差值的方法进一步分析脑白质细微结构变化具有临床意义,可用于临床分析。

Objective： To investigate the viability and significance of imaging measurement on the diffusion tensor tractography of white matter fibers. Materials and Methods： A study group of 50 patients suffering from schizophrenia, a control group of 50 healthy persons. Taking the above-mentioned 2 groups as subjects of study and making imaging tractography measurement on the diffusion tensor of the amount of white matter fibers among the two groups of people. Results：（1） No obvious significant difference statistically was found in contrasting the age and gender of the two groups of people.（2） The differences were significant statistically（P〈0.05） when comparing comparison between the two groups in terms of distribution differences between left and right parts of the brain. Tests on the study group showed that subjects in this group register lower volume in such aspects as bilateral temporal gyros, bilateral middle and outer bag hook back around bilateral hippocampal FA difference than the control group. The bigger the difference is the more statistical value the study shows. Conclusions： In measuring the FA value of white matter in the study group using diffusion tensor imaging, the researchers made symmetrical measurements on the clearest parts of the two levels of successive adjacent parts. When the FA value of white matter shown in the diffusion tensor tractography is found to be abnormal, bilateral FA value can be measured, the difference between the right side FA value and the left side FA value can be used in carrying out clinical analysis on microscopic structure chang of white matter.