帕金森病伴抑郁的MRI研究现状

The research status of magnetic resonance imaging in Parkinson's disease patients with depression

帕金森病(PD)是中老年人常见的神经系统变性疾病,常以运动障碍起病,但是非运动症状的发生率也非常高,其中抑郁症状发生率最高。抑郁症状的出现严重影响PD患者生活质量,也是加重运动障碍,认知损害,加速病情发展和影响疗效的重要因素,其发生机制尚不清楚。目前功能影像研究认为PD伴抑郁患者(PDD)的发病机制与多巴胺,5-羟色胺能神经元以及前额叶-边缘系统核团病变可能有关。

Parkinson＇s disease is a common neurodegenerative disease in the elderly,PD patients were mainly with the onset of motor disorders, but the incidence of non motor symptoms is also very high, the incidence of depression was the highest among the non motor symptoms. The symptoms of depression have a serious impact on the quality of life of patients with Parkinson＇s disease, and it is also an important factor to increase the motor impairment, cognitive impairment, accelerate the development of the disease and the effect of the treatment, but the mechanism is not clear. At present,functional imaging studies suggest that the pathogenesis of PD with depression may be related to the pathogenesis of dopamine neurons, 5- serotonin neurons and prefrontallimbic system.